Open Access Case Report

Acute Hepatic Insufficiency Disclosing Congenital Syphilis in a Neonate

M. A. Radouani, Y. Taboz, H. Benkirane, H. Aguenaou, M. Mrabet, A. Barkat

Journal of Advances in Medicine and Medical Research, Page 1-11
DOI: 10.9734/BJMMR/2016/22286

Congenital syphilis is a maternal-fetal infection caused by Treponema pallidum. Early signs are characteristic skin lesions, lymphadenopathy, hepatosplenomegaly, failure to thrive, blood-stained nasal discharge, perioral fissures, meningitis, choroiditis, hydrocephalus, seizures, intellectual disability, osteochondritis, and pseudoparalysis (Parrot atrophy of newborn).

We report the case of a new born on day 1 of life hospitalized for respiratory distress. Clinical examination showed signs of respiratory retraction with hypotonia. The assessment carried out revealed: severe liver insufficiency and infected cerebrospinal fluid (CSF) with sterile culture. The diagnosis of congenital syphilis in our patient was confirmed by a positive serology in the neonate and her mother. The outcome was fatal.

Open Access Short Research Article

Antibiotic Residues in Meat and Eggs in Taiwan: A Local Surveillance

Su-Ching Yang, Mei-Chu Yu, Yee-Hua Lee, Jiun-Ling Wang

Journal of Advances in Medicine and Medical Research, Page 1-6
DOI: 10.9734/BJMMR/2016/21922

Aims: To estimate the prevalence and identify risk factors of antibiotic residues in meats and eggs in Taiwan through a cross-sectional study.

Methodology: From 1 Jan 2013 to 31 Dec 2014, we collected 175 samples from supermarkets (eggs, n = 50; chicken meat, n = 50; pork meat, n = 50; and fish meat, n = 25) and 175 samples from wet markets (eggs, n = 50; chicken meat, n = 50; pork meat, n = 50; and fish meat, n = 25) in Taiwan. Most samples were purchased in southern Taiwan.

Results: In total, 350 samples were collected, and 8% were determined by the Premi®Test to contain antibiotic residues. Univariate analysis showed that the meat and eggs purchased from wet markets were more likely to have antibiotic residues than those purchased from supermarkets (12% vs. 4%, P = .006). Multivariate analysis showed that the suburban locale (odds ratio: 4.59; 95% confidence interval: 1.21–17.42) and the wet market type (odds ratio: 3.51; 95% confidence interval: 1.43–8.62) were two independent risk factors for meats and eggs to be positive for antibiotic residues.

Conclusion: The 2013–14 meat and egg surveillance for antibiotic residues found 8% rate of positive samples. The suburban locale and wet market type were two independent risk factors for antibiotic residues to be detected in meats and eggs in Southern Taiwan. Further surveillance of antibiotic residues in meats and eggs in these high risk areas may be necessary.

Open Access Short Research Article

Palmar Dermatoglyphic Patterns in Bronchial Asthma between Afro-Trinidadian and Indo-Trinidadian: A Comparative Study

Suresh R. Rao, Nelleen Baboolal, Bidyadhar Sa, T. Ramesh Rao

Journal of Advances in Medicine and Medical Research, Page 1-8
DOI: 10.9734/BJMMR/2016/22786

Background: Dermatoglyphics, the ridged skin covering our palms and sole, are not only found on human beings. All primates have ridged skin, and it can also be found on the paws of certain mammals and on the tails of some monkey species. Palmar creases develop during the 2nd and 3rd month of intrauterine life and are not influenced by movement of hand in utero. They are of considerable clinical interest because they are affected by certain abnormalities of early development including genetic disorders.

Aim: The present study is carried out to correlate the dermatoglyphic patterns in patients of bronchial asthma.

Methods: Dermatoglyphic prints were obtained from both hands of 100 patients of bronchial asthma among Afro-Trinidadian and Indo-Trinidadian. Hundred normal healthy individuals, without family history of bronchial asthma, were selected as control group. The qualitative parameters like whorls, loops and arches were studied in the above mentioned study groups.

Results: Presence of whorls loops and arches showed significant difference, p<0.01in III and IV digits in Afro-Trinidadian group and only in III digit in Indo-Trinidadian group when compared to the controls. The intergroup comparisons also showed significant changes in the percentage of all the finger print patterns in the II & III digit in Afro-Trinidadian bronchial asthma patient when compared with Indo-Trinidadian bronchial asthma patients. 

Conclusion: Presence of whorls, loops and arches on both the III digit can be used as one of the diagnostic criterion for patients with bronchial asthma.

Open Access Minireview Article

Application of Different Types of Magnet Retention Systems in the Prosthetic Practice

D. Veleski, B. Pejkovska Shahpaska, D. Veleska Stevkovska

Journal of Advances in Medicine and Medical Research, Page 1-7
DOI: 10.9734/BJMMR/2016/22015

The magnetic systems as retention units in overdentures are especially used in dental prosthetics designed ​​on the appropriate endodontically treated dental root. With the rapid development of materials and technology their application with overdentures on implants is enabled.

In dentistry for a long time magnets made ​​from alloys of aluminium - nickel - cobalt have been used with open field. Their success was limited because these magnets are susceptible to corrosion in contact with saliva and because their retention force is weaker than that retention offered by the mechanical attachments.

The preparation of the magnets from alloys of rare earth elements samarium and neodymium enabled greater magnetic force per unit size. Also a new generation of containers allows laser welding with which the protection of the magnetic units from salivary corrosion has been improved.

The interest in such attachments is growing which is justified, because the magnets, unlike mechanical attachments have the potential of unlimited duration and may be superior to either mechanical ball or bar attachments in achieving retention for overdentures. Moreover, the magnetic unit provides little resistance to lateral displacement, with which the impact of potentially damaging lateral forces on the retention tooth or implant is reduced.

Open Access Minireview Article

Influence of Diabetes Mellitus on Stroke

Hassan Abu Zaid, Parag Suresh Mahajan

Journal of Advances in Medicine and Medical Research, Page 1-10
DOI: 10.9734/BJMMR/2016/22937

Diabetes is known to be an independent risk factor for the development of stroke. Stroke accounts for 20% of deaths among patients with diabetes, and is seen more commonly in younger age group than in non-diabetics. This reflects the adverse impact on economy and constitutes a major burden on the families of these patients and the country as well. This review highlights the influence of diabetes on stroke in many aspects, aiming to share a positive input on this major health problem.

Open Access Original Research Article

A Case Study of Delayed Primary Suturing in Facial Injuries Following Animal Bites

Shrinivas Chavan, Vasant Pawar, S. K. T. Jain, Sachin Bansod, Mangala Sonvani, Manu S. Babu

Journal of Advances in Medicine and Medical Research, Page 1-8
DOI: 10.9734/BJMMR/2016/22634

Aims: To evaluate the role of delayed primary suturing in prevention of sepsis and achieving better cosmetic appearance in animal bite injuries over the head and neck areas.  

Study Design: Prospective observational study.

Place and Duration of Study: Department of Otorhinolaryngology at Govt. Medical College, Nanded, Maharasthra, (India) from a period of Jan 2009 to Dec 2013.

Methodology: A prospective observational study of 70 cases of patients presented to us in the form of injury to head and neck area by animal bites. In all patients we followed the standard norm for delayed primary closure in form of:

• Thorough wound toileting
• Equine Rabies Immunoglobulin at the site of wound in all patients
• Anti-Rabies vaccination
• Daily dressing
• Delayed primary suturing after 10 days

All patients were routinely followed up and assessed for wound sepsis, cosmesis and function.

Results: Among the animal bites, dog bite injuries were found to be most common facial injuries followed by swine and cat. In our study group of 70 patients which was dominated by males from second decade onwards showed a faint line of demarcation in sex distribution in children. Cosmetic outcome on comparing our study of delayed primary closure with Paschos NK et al. study healing by secondary intention, delayed primary suturing exhibited significantly better result with the mean score of (1.50) for VSS compared to healing by secondary intention group with mean score of (3.05) for VSS was recorded (p= 0.000) (95% CI 0.1516-0.1494).

Conclusion: Delayed primary closure exhibited improved cosmetic appearance when compared with healing by secondary intention.

Open Access Original Research Article

Revaluing the Tzanck Test: A Comparative Study with Direct Immunofluorescence for Herpes Virus

A. Rocher, A. Angeleri, J. Rofrano, R. Absi, L. Sardi Segovia, L. Palaoro

Journal of Advances in Medicine and Medical Research, Page 1-7
DOI: 10.9734/BJMMR/2016/22473

Introduction: Tzanck Test (TT) is a sensitive method applicable to mucocutaneous lesions. Direct immunofluorescence (DIF) for Simplex Herpes Virus (HSV) is now a simple, no routine clinical laboratory practice, allows to differentiate the types of virus.

Objectives: To evaluate the diagnostic sensitivity of Tzanck test vs DIF for herpetic lesions, and to know its usefulness as a complementary diagnostic tool to clinical skin lesions in patients with erosive, vesicular, bullous and pustular lesions.

Materials and Methods: The TT was carried out in 157 lesion patient’s samples admitted to the Laboratory of Cytology of our Hospital from 1 January 2010 until 30 December 2014. Smears were stained with Giemsa and in parallel we performed DIF for HSV-1, HSV-2 and Varicella Zoster over 112 samples.

Results: Of the total samples, 40 (25%) were unsatisfactory for cytodiagnosis. The TT was positive in 60 samples (38%), of which 55 (35%) showed cytopathic effect for Herpes virus, 2 (1.6%) samples showed characteristic inclusion bodies of Molluscum contagiosum infection (Henderson-Paterson bodies), 1 (0.6%) sample showed acantholytic cells typical of Pemphigus Vulgaris, 1 (0.6%) showed morphological characteristics of Incontinentia Pigmenti and 1 (0.6%) presented immature cells of lymphoid appearance. 64 samples were positive by DIF and 58 by TT for HSV. Specificity and sensitivity for TT were 100% and 88% respectively.

Conclusion: The TT should be appreciated as a useful tool in the diagnosis of skin lesions by the rapid implementation and their ease interpretation, as well as being affordable and accessible for most cytology laboratories.

Open Access Original Research Article

Plant-derived Tetranortriterpenoid, Methyl Angolensate Activates Apoptosis and Prevents Ehrlich Ascites Carcinoma Induced Tumorigenesis in Mice

Kishore K. Chiruvella, Mayilaadumveettil Nishana, Vidya Gopalakrishnan, Somasagara R. Ranganatha, Satish Kumar Tadi, Bibha Choudhary, Sathees C. Raghavan

Journal of Advances in Medicine and Medical Research, Page 1-10
DOI: 10.9734/BJMMR/2016/21952

Background: Cancer is a leading health problem throughout the world. For decades, natural plant products have been playing promising roles as anticancer agents.

Objective: The present study aims to investigate the chemotherapeutic potential of methyl angolensate (MA), purified from Soymida febrifuga in mice bearing carcinoma and examines the molecular basis for its anticancer actions.

Study Design: The inhibitory effects of MA treatment on the survival of mice bearing Carcinoma and adverse side effects of MA treatment in mice were analyzed.

Methods: Tumor volume, life span, histopathology, immunohistochemical (IHC) analysis, estimation of liver enzyme, alkaline phosphatase and metabolites, creatinine and urea.

Results: Oral administration of MA in mice with Ehrlich Ascites Carcinoma showed significant inhibition of tumor growth compared to untreated mice. We observed a significant increase in the life span (~4-fold) of tumor bearing animals following treatment with MA. MA affected tumor cell proliferation by activating intrinsic pathway of apoptosis without imparting any side effect on normal cells. MA treatment in mice showed no major side effects.

Conclusion: MA treatment showed significant inhibition of tumor growth by inducing apoptosis as well increased life span of mice, with no adverse side effects to normal cells. Altogether, the present in vivo study provides new insights of MA serving as a cancer chemotherapeutic agent.

Open Access Original Research Article

Is It Possible to Increase the Diagnosis Rates of Depression, Anxiety and Adult Attention Deficit Hyperactivity Disorders in Emergency Departments: A Prospective Study from Turkey?

Yuksel Kivrak, Gulsen Cigsar, Mehmet Hanifi Kokacya, Mehmet Fatih Ustundag

Journal of Advances in Medicine and Medical Research, Page 1-8
DOI: 10.9734/BJMMR/2016/22400

Aim: Psychiatric disorders are common in society, particularly among patients in hospitals and emergency departments. Physicians may overlook psychiatric disorders. Improper diagnosis and treatment of psychiatric disorders may have harmful effects on patients and society. Depression and anxiety may be present in emergency room patients, but prevalence of attention deficit hyperactivity disorder are unknown. We aimed determine whether it is possible to increase the rates of diagnosis of depression, anxiety disorders and Adult Attention Deficit Hyperactivity Disorders (ADHD), which are common in society, using psychiatric rating scales for patients.

Materials and Methods: Sociodemographic data form, Hospital Anxiety Depression Scale, Adult Attention Deficit Hyperactivity Disorder (ADHD) Self-Report Scale and Emergency Department Patient Satisfaction Survey were administered to randomly selected patients on randomly selected days over a 3-month period. Diagnoses in the hospital records and scale cutoff scores were compared.

Results: Depression was identified in 99 patients, anxiety disorder in 21, and ADHD in 11 of 223 patients. With these scales, the diagnosis rates of depression, anxiety, and ADHD increased from 0% to 49%, 25.2%, and 5.4%, respectively.

Conclusion: Scales that can be filled out by patients in emergency departments are useful for diagnosing psychiatric disorders. With the help of these scales, with a psychiatric assessment rates of diagnosis and treatment could be increased. We may expect personal, social, and economic improvement with an increase of diagnosis and treatment rates.

Open Access Review Article

A Review of Helicobacter pylori Infection in Patients with Diabetes Mellitus

Huseyin Savas Gokturk, Mehmet Demir

Journal of Advances in Medicine and Medical Research, Page 1-8
DOI: 10.9734/BJMMR/2016/21579

Gastrointestinal symptoms, such as abdominal discomfort, chronic abdominal pain, dysphagia, heartburn, nausea, vomiting, diarrhea and constipation are more common in patients with Diabetes Mellitus (DM) than in the general population. Studies published in the past two decades have suggested a link between Helicobacter pylori (H. pylori) infection and DM in many aspects. These include; higher H. pylori infection prevalence however the data on the prevelance of H. pylori infection in patients with DM are scanty and contradictory, the eradication rate of H. pylori seems to be lower in DM patients than in non-diabetic controls, control of dyspeptic symptoms with eradication as well as association with late complications in DM patients. The aim of the present review is to gain a better understanding of H. pylori infection in DM patients.