Role of Zinc in an Organism and Its Influence on Processes Leading to Apoptosis
M. A. Orlova *
M. V. Lomonosov Moscow State University, Faculty of Chemistry, 1/3, Leninskiye Gory, Moscow 119899, Russia.
A. P. Orlov
N. I. Pirogov Russian State Medical University, 1 Ostrovityanova St., Moscow 117997, Russia.
*Author to whom correspondence should be addressed.
Abstract
This review brings together and analyzes the problem of zinc effects on the body through apoptosis, also affecting the latest data in the study of process itself apoptosis. Also, the possibility of using zinc and its derivatives and its complexes in cancer treatment are discussed. The review also focuses on the biochemical problems that lead to various diseases occurring in conditions of excess or deficiency of intracellular zinc. Review includes more than 300 references and contains research over the past ~ 15 years, focusing on the latest data.
Keywords: Zinc, apoptosis, metallothioneins, superoxise dismutase, zinc fingers, angiotensin-converting enzyme, magnetic isotope effect, zinc-complex, zinc-transporters