Expressional Evaluation of Androgen Receptor in Transitional Cell Carcinoma of Urinary Bladder Patients
Arshad Rahmani *
Department of Bioscienes, Jamia Millia Islamia, New Delhi, India and Department of Medical Laboratory Science, College of Applied Medical Sciences, Qassim University, Kingdom of Saudi Arabia and Department of Pathology, Maulana Azad Medical College, New Delhi, India.
Mohammad Alzohairy
Department of Medical Laboratory Science, College of Applied Medical Sciences, Qassim University, Kingdom of Saudi Arabia.
A. K. Mandal
Department of Pathology, Maulana Azad Medical College, New Delhi, India.
Moshahid A. Rizvi
Department of Bioscienes, Jamia Millia Islamia, New Delhi, India.
*Author to whom correspondence should be addressed.
Abstract
The study was undertaken to evaluate the possible role of Androgen Receptor (AR) in relation to tumor grade, age, sex and urinary bladder cancer risk. Expression of AR detected by immunohistochemistry in 125 Transitional Cell Carcinoma and 100 control cases. Expression of AR was noticed in 28.8% cases. AR increased with increasing tumor grade. Expression of AR was seen to be significantly higher in male in the age group ≥ 50 years (p < 0.05). AR expression was found to be associated significantly with the tumor grades, age and sex suggesting that AR may be used as prognostic markers in the treatment of urinary bladder carcinomas.
Keywords: Androgen receptor, smoking, transitional cell carcinoma, urinary bladder, IHC