Problems and Perspectives in Diagnosis and Prevention of Ovarian Tumor Diseases
Petr G. Prokopenko *
Department of Biological Chemistry, N. I. Pirogov Russian State Medical University, Ostrovityanov St. 1, Moscow 117997, Russia.
Valentina Poltoranina
N. N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Kashirskoe Schosse 24, Moscow 115478, Russia.
Kirill I. Zhordania
N. N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Kashirskoe Schosse 24, Moscow 115478, Russia.
Olga Petrenko
N. N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Kashirskoe Schosse 24, Moscow 115478, Russia.
Innokenty M. Mokhosoev
N. N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Kashirskoe Schosse 24, Moscow 115478, Russia.
Alexander A. Terentiev
Department of Biological Chemistry, N. I. Pirogov Russian State Medical University, Ostrovityanov St. 1, Moscow 117997, Russia.
*Author to whom correspondence should be addressed.
Abstract
A set of embryonic proteins - potential markers for ovarian tumors is presented. More than ten new embryonic proteins have been tested, but no one strictly specific protein marker for diagnosis of ovarian tumors has been revealed. SOVA-1 is the most perspective marker for today. The special attention is given to peculiarities of evolution and mechanisms of early distribution of the tumor process. The role of pregnancy and “pregnancy specific glycoprotein”- PSG as a way of the ovary tumor disease prevention is discussed. An attempt to realize sources and logic of the disease is undertaken in the present work.
Keywords: Ovarian tumor - peculiarities of evolution and progress, embryonic proteins- perspectives of immunodiagnostics, pregnancy specific glycoprotein (PSG), pregnancy as prevention measure in case of ovarian tumor disease