A Comparison of Rheumatoid Arthritis Patients in Kuwait with Other Populations: Results from the KRRD Registry
Adeeba Al-Herz *
Amiri Hospital, Kuwait City, Kuwait.
Adel Al-Awadhi
Department of Medicine, Faculty of Medicine, Kuwait University, Kuwait.
Khulood Saleh
Farwania Hospital, Farwania Governorate, Kuwait.
Waleed Al-Kandari
Farwania Hospital, Farwania Governorate, Kuwait.
Eman Hasan
Amiri Hospital, Kuwait City, Kuwait.
Aqeel Ghanem
Mubarak Al-Kabeer Hospital, Hawally Governorate, Kuwait.
Fatemah Abutiban
Jahra Hospital, Jahra Governorate, Kuwait.
Ahmad Alenizi
Jahra Hospital, Jahra Governorate, Kuwait.
Mohammed Hussain
Amiri Hospital, Kuwait City, Kuwait.
Yaser Ali
Mubarak Al-Kabeer Hospital, Hawally Governorate, Kuwait.
Ahmad Khadrawy
Farwania Hospital, Farwania Governorate, Kuwait.
Ammad Fazal
Farwania Hospital, Farwania Governorate, Kuwait.
Khaled Mokaddem
miri Hospital, Kuwait City, Kuwait.
Beena Aftab
Jahra Hospital, Jahra Governorate, Kuwait.
Najaf Haider
Jahra Hospital, Jahra Governorate, Kuwait.
Ajaz Zaman
Mubarak Al-Kabeer Hospital, Hawally Governorate, Kuwait.
Ghada Mazloum
Mubarak Al-Kabeer Hospital, Hawally Governorate, Kuwait.
Youssef Bartella
Amiri Hospital, Kuwait City, Kuwait.
Sally Hamed
Amiri Hospital, Kuwait City, Kuwait.
Ahmed Al-Saber
Department of Mathematics, Kuwait Technical College, Kuwait.
*Author to whom correspondence should be addressed.
Abstract
Objective: Data on rheumatoid arthritis (RA) in Kuwait and The Middle East is scarce. Available data from Western countries may not be representative of the region. We describe RA patients in Kuwait and compare them with other RA populations and with Kuwaiti general population.
Methods: Adult RA patients from Kuwait Registry for Rheumatic Diseases (KRRD), the first RA registry in The Middle East, were studied from February 2013 through February 2015. Demographic, clinical and serologic data were compared with other RA populations and with Kuwaiti general population.
Results: 835 patients were enrolled, 62.3% female. Mean age 50.6±12 years and disease duration 6.1±6 years. RA was diagnosed at a mean age of 44.9±12 years. 17.1% had family history of autoimmune rheumatic diseases. 3.1% had rheumatoid nodules. Rheumatoid factor (RF) and anti-citrullinated peptide (ACPA) were detected in 75.6% and 57.8%, respectively. Both were positive in 49% (r=0.287, p=0.001). ANA was positive in 19.1%. Both ACPA and a combination of positive RF and ACPA were more in males (p=0.017, 0.004 respectively), whereas ANA was more in females (p=0.01). One third of male patients were smokers versus 1.9% of females. Smoking was correlated to RF (p=0.009) and ACPA (p=0,002). Difference in ACPA between genders was statistically explained by the predominance of smoking in males. Comorbidities included diabetes mellitus (DM) (20.8%), hypertension (20.2%), hyperlipidemia (10.5%) and coronary artery disease (CAD) (3.1%). 4 cases of cancer were reported.
Conclusion: RA population in Kuwait includes less women than other RA populations but more than Kuwaiti general population. Family history is more common. A higher positive ACPA in males was explained by smoking difference. Hypertension and hyperlipidemia were less reported than in both Kuwaiti general population and other RA populations. CAD was similar to other RA populations. DM was more reported, reflecting its high background prevalence in Kuwait.
Keywords: Rheumatoid arthritis, comorbidities, prevalence, registry, KRRD, Kuwait, Middle East, Arabs