Microbiota Evaluation and Extracellular Cytokine Profile in Patients Affected with Intraabdominal Infection
João Fernando Gonçalves Ferreira
Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brasil
João Baptista Rezende-Neto
Faculdade de Medicina, Universidade Federal de Minas Gerais; Belo Horizonte, Minas Gerais, Brasil and Hospital Risoleta Tolentino Neves, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brasil
Rogério Augusto Pinto-Silva
Faculdade de Medicina, Universidade Federal de Minas Gerais; Belo Horizonte, Minas Gerais, Brasil and Centro Especializado em Ultra-sonografia, Belo Horizonte, Minas Gerais, Brasil
Jaqueline Gontijo de Souza
Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brasil
Luiz de Macêdo Farias
Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brasil
Maria Auxiliadora Roque de Carvalho
Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brasil
Helton Santiago
Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brasil
José Carlos Serufo
Faculdade de Medicina, Universidade Federal de Minas Gerais; Belo Horizonte, Minas Gerais, Brasil
Simone Gonçalves dos Santos *
Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brasil
*Author to whom correspondence should be addressed.
Abstract
Failures in the control of infectious focus may be associated with Intra-abdominal infections (IAI)-driven sepsis. We evaluated the bacterial antimicrobial profile and the cytokine production in patients with IAI in Belo Horizonte, Brazil. To the analyses, Vitek 2 bioMérieux and BD-CBA Human Inflammatory Cytokines were used. Escherichia coli, Enterococcus faecalis and Bacteroides fragilis were predominant in this cohort. Enterobacteriaceae was resistant to at least 4 different antimicrobial classes and 80.0% of Acintobacter baumannii strains to imipenem. 81.8% of Staphylococcus spp. were methicillin-resistant. Penicillin and clindamycin resistance were found in 80.0% and 26.7% of anaerobes, respectively. IL-8 was found in all IAI secretions and in 93.5% of analyzed sera; while IL-6 was identified in 93.5% of patient’s serum and in 51.6% analyzed secretions. IL-10 was detected in 53.3% of patient’s serum. Our data indicates the relevance of further cytokine profile studies to better understanding the evolution of these processes.
Keywords: Intraabdominal infection, microbiogical study, citokines profile, anaerobes