Uncommon Clinical Features of Lower Lip Squamous Cell Carcinoma in an Elderly Woman
Francisco Perinni Netto
School of Dentistry, Santo Amaro University, Rua Prof. Enéas de Siqueira Neto, 340 - Jardim das Imbuias, São Paulo - SP, 04829-300, Brazil.
Jodkandlys Resende
School of Dentistry, Santo Amaro University, Rua Prof. Enéas de Siqueira Neto, 340 - Jardim das Imbuias, São Paulo - SP, 04829-300, Brazil.
Mariana Rodriguez
School of Dentistry, University of São Paulo, Av. Prof. Lineu Prestes, 2227 - Cidade Universitária, São Paulo - SP, 05508-000 Brazil.
Fabiana Martins *
School of Dentistry, Santo Amaro University, Rua Prof. Enéas de Siqueira Neto, 340 - Jardim das Imbuias, São Paulo - SP, 04829-300, Brazil and School of Dentistry, University of São Paulo, Av. Prof. Lineu Prestes, 2227 - Cidade Universitária, São Paulo - SP, 05508-000 Brazil.
*Author to whom correspondence should be addressed.
Abstract
Introduction: Lip squamous cell carcinoma (LSCC) of the lower lip is the most common malignant neoplasm in the oral region, strongly associated with chronic sun exposure.
Case Report: A 73-year-old woman presented with a persistent ulcer on the lower lip lasting two years. Clinical examination revealed a crusted nodule with discoloration and changes in the vermilion border. Histopathological analysis showed high-grade epithelial dysplasia, sunlight-induced connective tissue damage, and islands of neoplastic epithelial cells, findings consistent with LSCC. Following oncologic therapy referral, the patient remains in follow-up care with no recurrence and a favorable esthetic outcome.
Conclusion: Early diagnosis and close monitoring of potentially malignant oral disorders are critical steps in reducing disease complications and improving quality of life, especially in elderly patients. This case underlines the importance of considering actinic cheilitis as a warning sign for lip cancer in elderly patients.
Keywords: Squamous cell carcinoma, lower lip, actinic cheilitis, oral cancer