The 100 Most-cited Articles on Intracanal Medication: A Bibliometric Analysis

Hebertt Gonzaga dos Santos Chaves

Department of Restorative Dentistry, Universidade Federal de Minas Gerais (UFMG), School of Dentistry, Belo Horizonte, Minas Gerais, Brazil.

Pedro Cesar Gomes Titato

Department of Operative Dentistry, Endodontics and Dental Materials, Bauru School of Dentistry, University of São Paulo, Bauru, SP, Brazil.

Ana Carolina Soares Mendes

Department of Restorative Dentistry, Universidade Federal de Minas Gerais (UFMG), School of Dentistry, Belo Horizonte, Minas Gerais, Brazil.

Vilton Cardozo Moreira Dias

Department of Restorative Dentistry, Universidade Federal de Minas Gerais (UFMG), School of Dentistry, Belo Horizonte, Minas Gerais, Brazil.

Barbara Figueiredo

Department of Restorative Dentistry, Universidade Federal de Minas Gerais (UFMG), School of Dentistry, Belo Horizonte, Minas Gerais, Brazil.

Rodolfo Gonçalves Lima

Universidade Federal de Juiz de Fora (UFJF), School of Dentistry, Juiz de Fora, Minas Gerais, Brazil.

Gustavo Henrique Sousa

Pontifícia Universidade Católica de Minas Gerais (PUC Minas), Belo Horizonte, Minas Gerais, Brazil.

Marco Antônio Hungaro Duarte

Department of Operative Dentistry, Endodontics and Dental Materials, Bauru School of Dentistry, University of São Paulo, Bauru, SP, Brazil.

Luciano Tavares Angelo Cintra

Endodontics, São Paulo State University (UNESP), School of Dentistry, Araçatuba, SP, Brazil.

Carlos Roberto Emerenciano Bueno

Endodontics, São Paulo State University (UNESP), School of Dentistry, Araçatuba, SP, Brazil.

Bruno Martini Guimarães

School of Dentistry, Federal University of Alfenas (Unifal), Alfenas, Minas Gerais, Brazil.

Francine Benetti *

Department of Restorative Dentistry, Universidade Federal de Minas Gerais (UFMG), School of Dentistry, Belo Horizonte, Minas Gerais, Brazil.

*Author to whom correspondence should be addressed.


Abstract

Aims: To examine the 100 most cited papers on intracanal medication in endodontics and determine the major research trends, authors, institutions, and study types.

Study Design: Bibliometric analysis.

Methodology: Systematic literature search was performed in the Web of Science Core Collection to determine the 100 most cited papers on intracanal medication. Citations, publication year, journal, authorship, country, institution, study design, type of medication, and keywords were extracted. VOSviewer software was employed to create bibliometric maps. Analysis was performed using descriptive statistics, Spearman correlation, and Poisson regression (p < 0.05).

Results: The number of citations among the top 100 articles ranged from 1 to 429, with a positive correlation observed across citation counts in different databases. The years 2021 and 2022 had the highest concentration of highly cited articles (n = 13 each). The Journal of Endodontics was the most frequently represented journal (n = 33). Brazil was the leading contributor, with 47 articles, followed by the United States (n = 8), and Canada and Saudi Arabia (n = 5 each). In total, 28 countries were represented. São Paulo State University (UNESP) was the most productive institution (n = 11), and J.F. Siqueira Jr. was the most prolific author (n = 5). In vitro studies were the most common (n = 53). The most frequently used keywords were “endodontics” and “calcium hydroxide” (n = 42). Calcium hydroxide was the most studied medication, whether as control group or in association with other medicaments/vehicle, followed by 2% chlorhexidine gel. Other studies evaluated plant extracts, nanoparticles, bioactive glass, DAP, sodium hypochlorite, and corticosteroid-antibiotic combinations. Poisson regression showed that older articles were cited 5.83% more, while literature reviews were cited 47% less compared to systematic reviews.

Conclusion: This is the first bibliometric evaluation of the most-highly-cited articles on intracanal medication that identifies key studies, authors, and institutions, providing significant insight into research trends and gaps in endodontics.

Keywords: Bibliometry, citation analysis, calcium hydroxide, intracanal medication


How to Cite

Chaves, Hebertt Gonzaga dos Santos, Pedro Cesar Gomes Titato, Ana Carolina Soares Mendes, Vilton Cardozo Moreira Dias, Barbara Figueiredo, Rodolfo Gonçalves Lima, Gustavo Henrique Sousa, et al. 2025. “The 100 Most-Cited Articles on Intracanal Medication: A Bibliometric Analysis ”. Journal of Advances in Medicine and Medical Research 37 (6):186-216. https://doi.org/10.9734/jammr/2025/v37i65863.

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