Complications of Diabetes: Cardiovascular, Renal, and Neurological Implications
Mohamed Aboelmaaty
University of Minnesota, MN, USA.
Huseyin Erdem Ak
Bilecik Seyh Edebali University, Bilecik, Turkey.
Nithish Gaddam
Chalmeda Anand Rao Institute of Medical Sciences, Telangana, India.
Mehwish Aqueel
Rosalind Franklin University of Medicine and Science, Illinois, USA.
Masood Ahmed
BRD Medical College, Gorakhpur, India.
Muhammad Sohail S. Mirza *
Shandong University School of Medicine, Jinan, China.
Kholood Ahmed
Corewell health William Beaumont university hospital, Michigan, USA.
*Author to whom correspondence should be addressed.
Abstract
Diabetes mellitus poses significant health challenges primarily due to its severe complications affecting the cardiovascular, renal, and nervous systems. Chronic hyperglycemia drives these complications through mechanisms like oxidative stress, inflammation, and the formation of advanced glycation end products, manifesting as both microvascular and macrovascular damage. Cardiovascular complications, including stroke and coronary artery disease, represent the leading cause of mortality among diabetic patients. Renal involvement leads to diabetic nephropathy, characterized by kidney damage. Furthermore, metabolic and vascular disturbances cause neurological complications, notably diabetic neuropathy. Effective prevention and management of these complications rely on stringent blood glucose control, alongside lifestyle modifications and pharmacological interventions.
Keywords: Diabetes mellitus, chronic hyperglycemia, cardiovascular complications, diabetic nephropathy