Assessment of Biochemical Changes in Pregnancy Induced Hypertension (PIH) among Saudi Population at KAMC-Riyadh
Tarig Karar
Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Saud Bin Abdul-Aziz University, Riyadh, Saudi Arabia
Mohamed Abdel Fattah
Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Saud Bin Abdul-Aziz University, Riyadh, Saudi Arabia
Khaled Romaizan O. Alenazy
Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Saud Bin Abdul-Aziz University, Riyadh, Saudi Arabia
Mohammad Jamaan Alharbi
Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Saud Bin Abdul-Aziz University, Riyadh, Saudi Arabia
Fares Meshabab S. Alqahtani
Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Saud Bin Abdul-Aziz University, Riyadh, Saudi Arabia
Waleed Al Tamimi
Department of Pathology and Laboratory Medicine, National Guard Health Affairs, Riyadh, Saudi Arabia.
Ikram Al Hassan
Department of Pathology and Laboratory Medicine, National Guard Health Affairs, Riyadh, Saudi Arabia
Susan Grajo
Department of Pathology and Laboratory Medicine, National Guard Health Affairs, Riyadh, Saudi Arabia
Ivy Alquisalas
Department of Pathology and Laboratory Medicine, National Guard Health Affairs, Riyadh, Saudi Arabia
Shoeb Qureshi *
Research Unit, College of Applied Medical Sciences, King Saud Bin Abdul-Aziz University, Riyadh, Saudi Arabia
*Author to whom correspondence should be addressed.
Abstract
Background: One of the most common complications that affect around 2-5% pregnant women is elevated blood pressure defined as gestational hypertension.
Aims & Objective: To compare and correlate between plasma urea, creatinine, sodium, potassium, and plasma glucose and urine protein in pre-eclamptic and normotensive groups.
Materials and Methods: This is quantitative retrospective chart review study. It is an hospital based case control study involving data from 199 age – matched Saudi women, discharged from Obstetrics and Gynecology Department of King Abdul Aziz medical city during the period of 2013-2014. The data were collected following standard procedures and statistical analysis was done using independent t – test and correlation.
Results: The levels urea, creatinine, sodium, potassium in the serum, plasma glucose and urine protein were significantly elevated in pre-eclamptic women when compared to normotensives (p= 0.000, p= 0.000, p= 0.005, p= 0.000, p= 0.000, p= 0.000 respectively). There was a significant positive correlation between urea and protein, urea and creatinine (r=0.3 P=0.002), (r=0.7 p=0.000) respectively.
Conclusion: The elevated values of serum creatinine, urea, urine protein, sodium, potassium and plasma glucose preclude them to be useful for consideration as consistent predictive indicator(s) for pre-eclampsia or pregnancy related hypertension.
Keywords: Preeclampsia, proteinuria, obstetrics, gynecology, normotensive