Expression of Eotaxin and RANTES in Nasal Polyps versus Healthy Nasal Mucosa, a Case Control Study
Yasmin Nabiel *
Department of Medical Microbiology and Immunology, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
Ghada Barakat
Department of Medical Microbiology and Immunology, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
Omima Ali
Department of Medical Microbiology and Immunology, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
Asser El-Sharkawy
Department of Otorhinolarngology, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
*Author to whom correspondence should be addressed.
Abstract
Aims: To investigate the levels of the chemokines; eotaxin and RANTES in chronic rhinosinusitsis with nasal polyposis in comparison to their levels in control healthy nasal mucosa to evaluate if they might play a role in pathogenesis.
Study Design: We performed a prospective case control study.
Place of Study and Duration: This study was performed in Otorhinolarngology Department Mansoura University Hospitals, Egypt.
Methodology: It included 60 patients suffering from chronic rhinosinsuitis with nasal polyposis, in addition to 20 subjects that were included as control. Nasal tissue samples were collected from all cases and control to estimate the levels of eotaxin and RANTES by ELISA.
Results: The estimated levels of eotaxin and RANTES in nasal polyps were higher than their measured levels in healthy nasal mucosa from control group and the results were statistically significant.
Conclusion: The measured levels of eotaxin and RANTES suggest that they may have a role in pathogenesis of chronic rhinosinusitis with nasal polyposis and can be considered as a good target for medical therapy until supported by further studies.
Keywords: Nasal polyposis, eotaxin, RANTES, E-selectin, enzyme linked immunosorrbant assay