PTSD Treatment: An Inquiry into the Promising Potential of Psilocybin
Ibrahim L. Folorunsho *
General Directorate of Health Affairs, Najran 66393, Saudi Arabia.
Nkechinyere Mary Harry
Vinnytsia National Pirogov Medical University, Vinnytsia Oblast 21018, Ukraine.
Chukwubueze Obiajunwa
College of Health Sciences, Obafemi Awolowo University, Ile-Ife, Osun 220001, Nigeria.
Oluwatosin Arubuolawe
Manhattan Psychiatric Center, New York City, NY 10035, USA.
Adeniyi Kayode Busari
Emory University, Atlanta, GA 30322, USA.
Chidalu Ibeneme
University of Toledo, Toledo, OH 43606, USA.
Gibson O. Anugwom
Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX 77030, USA.
*Author to whom correspondence should be addressed.
Abstract
Post-Traumatic Stress Disorder (PTSD) is a debilitating mental health condition that can occur after experiencing or witnessing a traumatic event. The impact of PTSD extends beyond the individual, affecting families, communities, and society as a whole. This study aims to investigate the potential of psilocybin as a treatment for PTSD. Psilocybin, after being metabolized to psilocin, binds to various serotonergic receptors to exert some major effects such as a reduction in negative mood and an increase in optimism, enhanced ability for introspection and perceptual changes, a reduction in amygdala reactivity during emotion processing, and—as has been found in animal studies—an extinction of the fear response and increased hippocampal neurogenesis. However, psychedelics such as psilocybin may lead to brief episodes of nausea, vomiting, and physical discomfort. This study indicated that there is an urgent need for innovative therapies that could enhance the effectiveness of PTSD treatments. As this review highlights, psilocybin and some other psychedelics offer prospects for an additional method of treating PTSD. They have the potential to directly address PTSD symptoms and can also be used as an adjunct to psychotherapy.
Keywords: Post-traumatic stress disorder nausea, vomiting, psychotherapy, mental health