Sleep Disorders and Quality of Life of Women in Menopausal Transition and Postmenopausal Assisted in Primary Health Care: A Cross-Sectional Observational Study Protocol

Leandro Victor Silva Ribeiro

Department of Rehabilitation and Health Sciences, University of the State of Minas Gerais - Divinópolis Unit, Divinópolis, Minas Gerais, Brazil.

Luísa Teixeira Pasqualotto

Physiotherapy, School of Medical Sciences, Postgraduate Program in Surgical Sciences, University of Campinas, Campinas, São Paulo, Brazil.

Newton Santos de Faria Júnior *

Physiotherapy, Department of Rehabilitation and Health Sciences, University of the State of Minas Gerais - Divinópolis Unit, Divinópolis, Minas Gerais, Brazil.

*Author to whom correspondence should be addressed.


Aims: The objective of the study will be to evaluate the presence of sleep disorders, sleep quality and life of women in the menopausal transition and postmenopausal assisted in primary health care (PHC) in Divinópolis/MG.

Study Design: Cross-sectional observational.

Place and Duration of Study: PHC in the municipality of Divinópolis, Minas Gerais, Brazil, between January and December 2023.

Material and Methods: The present study will be carried out by professors and students of the University of the State of Minas Gerais (UEMG), Divinópolis Unit, with women recruited from PHC in the municipality of Divinópolis/MG, after consenting to participate in the study, by signing the Informed Consent Form (ICF). The sample will be consecutive and of convenience and then stratified according to sociodemographic variables, presence or absence of sleep disorders, sleep quality, quality of life and other variables pertinent to the study.

Discussion: Due to the lack of professional performance in primary care for sleep disorders,                           it is necessary to study the concomitant changes between the menopausal transition and postmenopausal processes. Given the aspects related to these disorders, there is a need for a more in-depth look at the factors that can interfere with sleep quality during this transition.

Conclusion: This study protocol aims to investigate sleep disorders and the quality of sleep and life in women during the menopausal and postmenopausal transition phases. The research seeks to identify data demonstrating the changes that occur during these phases.

Keywords: Primary health care, sleep wake disorders, Postmenopause, climateric

How to Cite

Ribeiro, Leandro Victor Silva, Luísa Teixeira Pasqualotto, and Newton Santos de Faria Júnior. 2024. “Sleep Disorders and Quality of Life of Women in Menopausal Transition and Postmenopausal Assisted in Primary Health Care: A Cross-Sectional Observational Study Protocol”. Journal of Advances in Medicine and Medical Research 36 (7):348-56.


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Brazilian Institute of Geography and Statistics. Social Statistics; 2020. Available: 6 years. Accessed July 19, 2022.

Warren MP. Missed symptoms of menopause. Int J Clin Pract. 2007;61(12): 12.

Mustafa MM, Souza EPP, Sena AB. Early menopause in Brazil: An integrative literature review. Res Soc Dev. 2021;10 (14):1-8.

Stojanovska L, Apostolopoulos V, Polman R, Borkoles E. To exercise, or, not to exercise, during menopause and beyond. Maturitas. 2014;77(4):318-23.

Kravitz HM, Ganz PA, Bromberger J. Sleep difficulty in women at midlife: A community survey of sleep and the menopausal transition. Menopause. 2003;10(1):19 -28.

Kravitz HM, Joffe H. Sleep during the perimenopause: a SWAN story. Obstet Gynecol Clin North Am. 2011;38(3):567-86.

Lee J, Han Y, Cho HH, Kim MR. Sleep Disorders and Menopause. J Menopausal Med. 2019;25(2):83-7.

Jayadharani C, Devi RG, Priya AJ. Effect of peppermint oil among sleep apnea individuals, Journal of Pharmaceutical Research International. 2020;32(26):98–101. DOI: 10.9734/jpri/2020/v32i2630843

Thorpy MJ. Classification of sleep disorders. Neurotherapeutics. 2012;9(4): 687-701.

Ophoff D, Slaats MA, Boudewyns A, Glazemakers I, Van Hoorenbeeck K, Verhulst SL. Sleep disorders during childhood: A practical review. European Journal of Pediatrics. 2018;177:641-8.

Dement WC. A personal history of sleep disorders medicine. J Neurophysiol Clin. 1990;7(1):17-48.

Neves GSML, Macedo P, Gomes MMG. Sleep Disorders: Update (1/2). Rev Bras Neurol. 2017;53(3):19-30

Buckworth J, Dishman RK. Exercise psychology. 2nd ed. Champaign: Human Kinetics. 2002;1-528.

Morphy H, Dunn KM, Lewis M, Boardman HF, Croft PR. Epidemiology of insomnia: A longitudinal study in a UK population. Sleep. 2007;30(3):274-80.

Ohayon MM, Reynolds CF. Epidemiological and clinical relevance of insomnia diagnosis algorithms according to the DSM-IV and the International Classification of Sleep Disorders (ICSD). Sleep Med. 2009;10(9):952-60.

Leblanc M, Mérette C, Savard J, Ivers H, Baillargeon L, Morin CM. Incidence, and risk factors of insomnia in a population-based sample. Sleep. 2009;32(8):1027- 37.

Krystal AD, et al. Sustained efficacy of eszopiclone over 6 months of nightly treatment: Results of a randomized, double-blind, placebo-controlled study in adults with chronic insomnia. Sleep. 2003;26(7): 793-9.

Zhang B, Wing YK. Sex Differences in Insomnia: A Meta-Analysis. Sleep. 2006;29 (1):85-93.

Ballot O, Ivers H, Morin JCM. Sleep Disturbances During the Menopausal Transition: The Role of Sleep Reactivity and Arousal Predisposition. Behav Sleep Med. 2021;20(4):500-12.

ouza CL, Aldrighi JM, Filho GL. Sleep quality in climacteric women from São Paulo. Rev Assoc Med Bras. 2005;51(3):3

Sánchez-de-la-Torre M, Campos-Rodriguez F, Barbé F. Obstructive sleep apnea and cardiovascular disease. Lancet Respir Med. 2013;1(1):61-72.

Peppard TE, Young T, Barnet JH, Palta M, Hagen EW, Hla KM. Increased prevalence of sleep-disordered breathing in adults. Am J Epidemiol. 2013;177(9):1006-14.

Koo SK, et al. Obstructive sleep apnea in postmenopausal women: A comparative study using drug induced sleep endoscopy. Braz J Otorhinolaryngol. 2017;83(3):285-91.

Silva K, Cattani AN, Hirt MC, Peserico A, Silva RM, Beck CLC. Excessive daytime sleepiness and the effects of work on the health of nursing workers. Global Sick. 2020;58(58):276-88.

Gooneratne NS, et al. Functional outcomes of excessive daytime sleepiness in older adults. J Am Geriatr Soc. 2003;51 (5):642-9.

Guimarães CLH, Carvalho LB, Yanaguibashi G, Prado GF. Physically active elderly women sleep more and better than sedentary women. Sleep Med. 2008;9(5):94-488.

Spindola T, Santos RS. Women and work – The life story of working mothers in nursing. Rev Lat Am Enfermagem. 2003; 11(5):593-600.

Portela GZ. Primary Health Care: an essay on concepts applied to national studies. Physis. 2017;27(2): 255-76.

Brazil. Ordinance No. 2,436, of September 21, 2017. Consolidation of standards on national health policies of the Unified Health System. National Primary Care Policy (PNAB). Official Gazette of the Federative Republic of Brazil. Brasília DF, art. 2., September 21; 2017.

Vieira TMM, et al. Experiencing the climacteric: Perceptions and experiences of women treated in primary care. Nursing Focus. 2018;9(2):40-5.

Pimenta FAP, et al. Assessment of the quality of life of retirees using the SF-36 questionnaire. Rev Assoc Med Bras. 2008;54(1):55-60.

Von EE, Altman DG, Egger M, Pocock SJ, Gotzsche PC, Vandenbroucke JP. Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies. BMJ. 2007;335(4):806-8.

Malta M, Cardoso LO, Bastos FI, Magnanini MMF, Silva CMF. STROBE initiative: Guidelines on reporting observational studies. Rev Saude Publica. 2010;44(3):559-65.

World Health Organization (WHO). Obesity: Preventing and managing the global epidemic. Report of a WHO Consultation. WHO Tech Rep Ser. 2000; 894(1):1-253.

Zen V, Fuchs FD, Wainstein MV. Neck circumference and central obesity are independent predictors of coronary artery disease in patients undergoing coronary angiography. Am J Cardiovasc Dis. 2012;2 (4):323-30.

World Health Organization (WHO). Obesity: preventing and managing the global epidemic. Report of a WHO Consultation. WHO Tech Rep Ser. 2000; 894(1):1-253.

Buysse DJ, Reynolds CF, Monk TH, Berman SR, Kupfer DJ. The Pittsburgh Sleep Quality Index: A new instrument for psychiatric practice and research. Psychiatry Res. 1989;28(2):193-213.

Bertolazi NA, Fagondes SC, Hoff LS, Dartora EG, Miozzo IC, Barba ME. Validation of the Brazilian Portuguese version of the Pittsburgh Sleep Quality Index. Sleep Med. 2011;5(1):12-70.

Ribeiro HL, et al. Clinical-epidemiological profile of excessive daytime sleepiness in terms of its assessment through the application of subjective sleep scales: Epworth Sleepiness Scale and Pittsburgh Sleep Quality Index. Rev Uningá. 2020; 57(1):39-50.

Bastien CH, Vallieres A, Morin CM. Validation of the Insomnia Severity Index as an outcome measure for insomnia research. Sleep Med. 2001;2(4):297-307.

Castro LS. Adaptation and validation of the Insomnia Severity Index (IGI): Population characterization, normative values and associated aspects. [dissertation]. São Paulo. 2011;1-104.

Johns MW. A new method for measuring daytime sleepiness: the Epworth sleepiness scale. Sleep. 1991;14(6):540-5.

Bertolazi AN, Fagondes SC, Hoff LS, Pedro D, Barreto SSM, Johns MW. Portuguese-language version of the epworth sleepiness scale: Validation for use in Brazil. J Bras Pneumol. 2009;35(1): 877-83.

Netzer NC, Stoohs RA, Netzer CM, Clark K, Strohl KP. Using the Berlin Questionnaire to identify patients at risk for the sleep apnea syndrome. Ann Intern Med. 1999;131(7):485-91.

Ware JJ, Sherbourne CD. The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection. Med Care. 1992;30(6):83- 473.

Ciconelli RM, Ferraz MB, Santos W, Meinão I, Quaresma MR. Translation into Portuguese and validation of the generic quality of life assessment questionnaire SF-36 (Brazil SF-36). Rev Bras Reumatol. 1999;39(3):143-50.

Potthoff P, Heinemann LAJ, Schneider HPG, Rosemeier HP, Hauser GA. Menopause Rating Scale (MRS): Methodological standardization in the German population. Central Gynacol. 2000;122(5):280-6.

Heinemann K, Assmann A, Möhner S, Schneider HPG, Heinemann LAJ. Reliability of the Menopause Rating Scale (MRS). Study for the German population. Central Gynacol. 2002;124(3):161-3.

Heinemann LA, Potthoff P, Schneider HPG. International versions of the Menopause Rating Scale (MRS). Health Qual Life Outcomes. 2003;30(1):28.

Brown L, Hunter MS, Chen R, Crandall CJ, Gordon JL, Mishra GD, Rother V, Joffe H, Hickey M. Promoting good mental health over the menopause transition. The Lancet. 2024;403(10430): 969-83.

Terzic S, Bapayeva G, Kadroldinova N, Sarria-Santamera A, Gusmanov A, Semenova Y, Aimagambetova G, Laganà AS, Chiantera V, Ukybassova T, Kongrtay K. Menopausal Status Impact on the Quality of Life in Kazakhstani Healthcare Workers: A Cross-sectional Study. Journal of General Internal Medicine. 2024;1-9.