The Clinical Presentations and Endothelial Cell Analyses after Intra- Stromal Ring Implantation: A Systematic Review of Literature

Igor Jordan Barbosa Coutinho

Department of Ophthalmology, Federal University of Pará, Brazil.

José Jesu Sisnando D’Araújo Filho

Department of Ophthalmology, Federal University of Pará, Brazil.

Eduardo Henrique Herbster Gouveia

Department of Ophthalmology, Federal University of Pará, Brazil.

Bruno Eduardo Silva de Oliveira

Department of Ophthalmology, Federal University of Pará, Brazil.

Evelly Christinne da Silva Moraes

Department of Ophthalmology, Federal University of Pará, Brazil.

Camilla Castilho Maia

Department of Ophthalmology, Federal University of Pará, Brazil.

Paulo Armando Miranda Rosa da Silva

Department of Ophthalmology, Federal University of Pará, Brazil.

Maria Isabel Muniz Zemero

Department of Ophthalmology, Federal University of Pará, Brazil.

Déborah Silva Nunes

Department of Ophthalmology, Federal University of Pará, Brazil.

Ryan Jorge Amorim

Department of Ophthalmology, Federal University of Pará, Brazil.

Kylza Beatriz Souza de Oliveira

Pará University Center, Brazil.

Vitor Hugo Auzier Lima *

Department of Biotechnology, Paulista University, Brazil and Independent Researcher, ONE Company, Brazil.

*Author to whom correspondence should be addressed.


Intrastromal ring implantation has been an important therapeutic option for various corneal refractive disorders. In this study, a systematic review of the literature was carried out with the aim of understanding the clinical panorama and changes in endothelial cells following this procedure. It was considered relevant to explore the diversity of perspectives and approaches presented by existing studies, as well as to highlight gaps in knowledge to guide future research. To this end, a comprehensive search strategy in electronic databases was used to identify relevant studies published to date. The inclusion criteria were carefully applied to select articles that specifically addressed the topic in question. A qualitative and quantitative analysis of the data extracted from the included studies was carried out, seeking to identify patterns and trends in the clinical outlook and in the analyses of endothelial cells following intra- stromal ring implantation. The analysis of the included studies revealed a variety of findings related to the clinical panorama after intrastromal ring implantation. A correlation was observed between the clinical effects observed and the changes in endothelial cells, although the long-term stability of these results still requires further investigation. In addition, a relationship was identified between preoperative parameters and post-implant visual acuity, highlighting the importance of carefully evaluating these aspects when selecting candidates for the procedure. From this we can conclude that this systematic review of the literature has provided a comprehensive overview of clinical and endothelial cell analyses following intrastromal ring implantation. The results highlight the complexity of this area of research and point to the ongoing need for research to improve the understanding, application and optimization of already consolidated and innovative therapeutic measures in this field.

Keywords: Intra-stromal ring implantation, intrastromal ring, ophthalmology, keratoconus

How to Cite

Coutinho, Igor Jordan Barbosa, José Jesu Sisnando D’Araújo Filho, Eduardo Henrique Herbster Gouveia, Bruno Eduardo Silva de Oliveira, Evelly Christinne da Silva Moraes, Camilla Castilho Maia, Paulo Armando Miranda Rosa da Silva, Maria Isabel Muniz Zemero, Déborah Silva Nunes, Ryan Jorge Amorim, Kylza Beatriz Souza de Oliveira, and Vitor Hugo Auzier Lima. 2024. “The Clinical Presentations and Endothelial Cell Analyses After Intra- Stromal Ring Implantation: A Systematic Review of Literature”. Journal of Advances in Medicine and Medical Research 36 (7):168-86.


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