Lighting the Path: Evaluating Light-Emitting Diode Therapy Versus Salicylic Acid Peel for Inflammatory Acne- A Case Series Analysis

Diogo, MLG *

Universidade Nove de Julho, São Paulo, SP, Brazil.

Carvalho, FGM

Universidade Nove de Julho, São Paulo, SP, Brazil.

Santos, RCS

Universidade Adventista de São Paulo, SP, Brazil.

Dourado, LF

Universidade Adventista de São Paulo, SP, Brazil.

Matuck, SP

Universidade Nove de Julho, São Paulo, SP, Brazil.

Fernandes, KPS

Universidade Nove de Julho, São Paulo, SP, Brazil.

Pavani, C

Universidade Nove de Julho, São Paulo, SP, Brazil.

Motta, LJ

Universidade Nove de Julho, São Paulo, SP, Brazil.

*Author to whom correspondence should be addressed.


Aims: This study aims to assess the efficacy of red, blue, and combined red-blue light therapy versus 20% salicylic acid peel in treating Grades 2 and 3 inflammatory acne.

Study Design: Cases studies.

Place and Duration of Study: Universidade Nove de Julho, Universidade Adventista de São Paulo, São Paulo Brazil. Between March 2022 from April 2024.

Introduction: Acne is an inflammatory disorder that occurs in the pilosebaceous follicles and deeply affects the self-esteem and quality of life of individuals. Conventional treatments usually produce side effects and promote antibiotic resistance. Light therapy has emerged as a promising modality in clinical and scientific realms for acne management. This study aims to evaluate the effectiveness of red, blue and combined red-blue light therapy versus 20% salicylic acid peeling in the treatment of inflammatory acne grade 2 and 3.

Methodology: We divided 20 participants into four groups who used a mask of LEDs.  Group 1 used a mask with blue light (470nm), group 2 used a mask with red light (660nm), group 3 used a mask with red (660nm) and blue (470nm) lights combined in the same device. The groups that used the LED masks received the treatment 3 times a week for 30 days, totaling 12 sessions.  Group 4 was submitted to two sessions of salicylic acid peeling at 20%, every 15 days.

Results: Blue light (group 1) showed an improvement of 28.40% in the general skin condition. Group 4 of salicylic acid peeling had an improvement of 28.37%. The combined red and blue light group had an improvement of 26.43%, while the red light showed an improvement of 10.97%.

Conclusion:  Based on the series of cases presented, all groups showed improvement, but blue light showed higher results than red light and salicylic acid. However, studies with a larger number of participants should be performed and the ideal parameters for Led use in inflammatory acne should be discussed.

Keywords: Inflammatory acne, photo biomodulation, LLLT, LED

How to Cite

MLG, Diogo, Carvalho, FGM, Santos, RCS, Dourado, LF, Matuck, SP, Fernandes, KPS, Pavani, C, and Motta, LJ. 2024. “Lighting the Path: Evaluating Light-Emitting Diode Therapy Versus Salicylic Acid Peel for Inflammatory Acne- A Case Series Analysis”. Journal of Advances in Medicine and Medical Research 36 (7):120-31.


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Williams HC, Dellavalle RP, Garner S. Acne vulgaris. Lancet. 2012;379:361–372.

Layton AM, Thiboutot D, Tan J. Reviewing the global burden of acne: how could we improve care to reduce the burden? Br J Dermatol. 2021;184(2):219-225. DOI: 10.1111/bjd.19477. Epub 2020 Sep 24. PMID: 32770673.

Van Onselen J. Acne management and patient support - a nursing concern for all. Br J Nurs. 2010;19(1):18-23. DOI:10.12968/bjon.2010.19.1.45906. PMID: 20081707.

Figueiredo A, Massa A, Picoto A, Soares A, Basto A, Lopes C, Bello R. Avaliação e tratamento do doente com acne—Parte I: Epidemiologia, etiopatogenia, clínica, classificação, impacto psicossocial, mitos e realidades, diagnóstico diferencial e estudos complementares. Rev. Soc. Port. Med. Interna. 2011;27:59–65.

Makrantonaki E, Ganceviciene R, Zouboulis CC. An update on the role of the sebaceous gland in the pathogenesis of acne. Dermato-Endocrinology. 2011;3:41–49.

Gollnick HP, Zouboulis CC. Not All Acne Is Acne Vulgaris. Dtsch. Ärzteblatt Int. 2014;111:301.

Greydanus DE, Azmeh R, Cabral MD, Dickson CA, Patel DR. Acne in the first three decades of life: An update of a disorder with profound implications for all decades of life. Dis Mon. 2021;67(4): 101103.

Doi:10.1016/j.disamonth.2020.101103. Epub 2020 Oct 9. PMID: 33041056.

Rao A, Douglas SC, Hall JM. Endocrine Disrupting Chemicals, Hormone Receptors, and Acne Vulgaris: A Connecting Hypothesis. Cells. 2021;10(6): 1439. DOI:10.3390/cells10061439. PMID: 34207527; PMCID: PMC8228950.

Zaenglein AL. Acne Vulgaris. N Engl J Med. 2018;379(14):1343-1352. DOI: 10.1056/NEJMcp1702493.

PMID:30281982 Avaialble:

Habeshian KA, Cohen BA. Current Issues in the Treatment of Acne Vulgaris. Pediatrics. 2020;145(Suppl 2):S225-S230. DOI: 10.1542/peds.2019-2056L. PMID: 32358215.

Gollnick HP, Bettoli V, Lambert J, Araviiskaia E, Binic I, Dessinioti C, Galadari I, Ganceviciene R, Ilter N, Kaegi M, Kemény L. A consensus‐based practical and daily guide for the treatment of acne patients. Journal of the European Academy of Dermatology and Venereology. 2016;30(9):1480-90.

Kosmadaki M, Katsambas A. Topical treatments for acne. Clin Dermatol. 2017; 35(2):173-178.

DOI :10.1016/j.clindermatol.2016.10.010. Epub 2016 Oct 27. PMID: 28274355.

Lu J, Cong T, Wen X, Li X, Du D, He G, Jiang X. Salicylic acid treats acne vulgaris by suppressing AMPK/SREBP1 pathway in sebocytes. Exp Dermatol. 2019;28(7):786-794. DOI: 10.1111/exd.13934. Epub 2019 May 15. PMID: 30972839.

Marson JW, Baldwin HE. An Overview of Acne Therapy, Part 1: Topical therapy, Oral Antibiotics, Laser and Light Therapy, and Dietary Interventions. Dermatol Clin. 2019;37(2):183-193. DOI:10.1016/j.det.2018.12.001. Epub 2019 Feb 14. PMID: 30850041.

Baldwin H. Oral Antibiotic Treatment Options for Acne Vulgaris. J Clin Aesthet Dermatol. 2020;13(9):26-32. Epub 2020 Sep 1. PMID: 33133338; PMCID: PMC7577330.

Del Rosso JQ, Rosen T, Palceski D, Rueda MJ. Patient Awareness of Antimicrobial Resistance and Antibiotic Use in Acne Vulgaris. J Clin Aesthet Dermatol. 2019;12(6):30-41.

Epub 2019 Jun 1. PMID: 31360286; PMCID: PMC6624010.25)

HAMBLIN MR. Introduction to experimental and clinical studies using low-level laser (light) therapy (LLLT). Lasers Surg Med. 2010;42(6):447-9.

KARU TI. Cellular and molecular mechanisms of photobiomodulation (Low-Power Laser Therapy). IEEE Journal of Selected Topics in Quantum Electronics. 2014;20:2.

Mester E, Szende B, Gärtner P. Die Wirkung der Lasstrahlen auf den Haarwuchs der Maus [The effect of laser beams on the growth of hair in mice]. Radiobiol Radiother (Berl). 1968;9(5):621-6.

PMID: 5732466.

Barolet D. Light-emitting diodes (LEDs) in dermatology. Semin Cutan Med Surg. 2008;27(4):227-38.

DOI: 10.1016/j.sder.2008.08.003. PMID: 19150294.

Kim WS, Calderhead RG. Is light-emitting diode phototherapy (LED-LLLT) really effective? Laser Ther. 2011;20(3):205-15. DOI:10.5978/islsm.20.205. PMID: 24155530; PMCID: PMC3799034.

Papageorgiou P, Katsambas A, Chu A. Phototherapy with blue (415 nm) and red (660 nm) light in the treatment of acne vulgaris. Br. J. Dermatol. 2000;142:973–978.

Elman M, Slatkine M, Harth Y. The effective treatment of acne vulgaris by a high-intensity, narrow band 405-420 nm ligh source. J. Cosmet. Laser Ther. 2003; 5:111–117.

Arif T. Salicylic acid as a peeling agent: a comprehensive review. Clin Cosmet Investig Dermatol. 2015;8:455-61. DOI: 10.2147/CCID.S84765. PMID: 26347269; PMCID: PMC4554394.

Mavranezouli I, Welton NJ, Daly CH, Wilcock J, Bromham N, Berg L, Xu J, Wood D, Ravenscroft JC, Dworzynski K, Healy E. Cost-effectiveness of topical pharmacological, oral pharmacological, physical and combined treatments for acne vulgaris. Clin Exp Dermatol. 2022;47(12): 2176-2187. DOI: 10.1111/ced.15356. Epub 2022 Oct 18. PMID: 36258288; PMCID: PMC10091701.

Schachner LA, Alexis AF, Andriessen A, Berson D, Gold M, Goldberg DJ, Hu S, Keri J, Kircik L, Woolery-Lloyd H. Insights into acne and the skin barrier: Optimizing treatment regimens with ceramide-containing skincare. J Cosmet Dermatol. 2023;22(11):2902-2909. DOI: 10.1111/jocd.15946. Epub 2023 Aug 21. PMID: 37605504.

Van Onselen J. Acne management and patient support - a nursing concern for all. Br J Nurs. 2010;19(1):18-23. DOI:10.12968/bjon.2010.19.1.45906. PMID: 20081707.

Sadowska M, Narbutt J, Lesiak A. Blue Light in Dermatology. Life (Basel). 2021; 11(7):670. DOI:10.3390/life11070670. PMID: 34357042; PMCID: PMC8307003.

Garza ZCF, Born M, Hilbers PAJ, van Riel NAW, Liebmann J. Visible Blue Light Therapy: Molecular Mechanisms and Therapeutic Opportunities. Curr Med Chem. 2018;25(40):5564-5577. DOI:10.2174/0929867324666170727112206. PMID: 28748760.