Disseminated Histoplasmosis in an Immunocompetent Patient from a Non Endemic Region, North India: Pointers to Potential Endemicity
Aarti Kotwal
Department of Microbiology, Himalayan Institute of Medical Sciences, Jolly Grant, Dehradun-248140, India.
Debasis Biswas *
Department of Microbiology, Himalayan Institute of Medical Sciences, Jolly Grant, Dehradun-248140, India.
Shailendra Raghuvanshi
Department of Radiodiagnosis, Himalayan Institute of Medical Sciences, Jolly Grant, Dehradun-248140, India.
Nadia Shirazi
Department of Pathology, Himalayan Institute of Medical Sciences, Jolly Grant, Dehradun-248140, India.
Barnali Kakati
Department of Microbiology, Himalayan Institute of Medical Sciences, Jolly Grant, Dehradun-248140, India.
*Author to whom correspondence should be addressed.
Abstract
Progressive Disseminated Histoplasmosis (PDH) reported worldwide is yet a rare entity in India. Although, usually associated with an underlying immunocompromised state but few reports of this disease in non- immunocompetent individuals have been surfacing in last decade. We report PDH from Himalayan state of Uttarakhand North India in an agriculturist, non immunocompromised who responded well to treatment with no evidence of recurrence of the disease. Of late a number of cases are being reported from this region, an indication that this might be a hot spot of Histoplasma capsulatum.
Keywords: Progressive disseminated histoplasmosis, immunocompetent, Histoplasma capsulatum var capsulatum, amphotericin, antifungal resistance