Overlap Syndrome: Systemic Lupus Erythematosus and ANCA Vasculitis in a Case Report
Hanane Benjelloun
Department of Pulmonology, CHU Ibn Rochd Casablanca, Morocco.
Asmaa Rattal *
Department of Pulmonology, CHU Ibn Rochd Casablanca, Morocco.
Afaf Amir
Department of Pulmonology, CHU Ibn Rochd Casablanca, Morocco.
Hanaa Harraz
Department of Pulmonology, CHU Ibn Rochd Casablanca, Morocco.
Nahid Zaghba
Department of Pulmonology, CHU Ibn Rochd Casablanca, Morocco.
Khadija Chaanoun
Department of Pulmonology, CHU Ibn Rochd Casablanca, Morocco.
Najiba Yassine
Department of Pulmonology, CHU Ibn Rochd Casablanca, Morocco.
*Author to whom correspondence should be addressed.
Abstract
Introduction: Microscopic polyangiitis is a systemic necrotising vasculitis that predominantly affects small-calibre vessels. It may be associated with systemic lupus erythematosus (SLE) as part of an overlap syndrome, but there are very few reports of this in the literature.
Case Report: We report the case of a 19-year-old patient admitted with moderate haemoptysis, epistaxis and petechial purpura revealing intra-alveolar haemorrhage with a strongly positive P-ANCA. In addition, blood tests for antinuclear antibodies and rheumatoid factor were positive, with renal involvement suggesting associated lupus as part of an overlap syndrome. Progression was good with corticoide and immunosuppressant treatment.
Conclusion: The clinical presentation of overlap syndrome is rare and severe, with a dual immunological profile of antinuclear antibodies and neutrophil cytoplasm.
Keywords: Overlap, treatment, Lupus, corticoids, haemorrhage