Evaluation of Injectable Platelet-rich Fibrin (i-PRF) as an Autologous Tissue Regenerator in Facial Aesthetics

Fernanda Pirossi Brodt *

University of Paraiba Valley, Sao Paulo, Brazil.

Roberto Puertas Garcia

Research Support Foundation – FAPES, São Paulo, Brazil.

Michelle Fechine Costa

University of Manchester, England.

Carolyne Martins De Marchi

University of Sao Paulo, Bauru Campus, Brazil.

Paulo Roxo Barja

University of São Paulo, Brazil.

Anelise Cristina Osorio Cesar Doria

University of Paraiba Valley, Sao Paulo, Brazil.

Gisele Rosada Donola Furtado

International Association of Orofacial Harmonisation – ASSIHOF, Sao Paulo, Brazil.

Kledson Lopes Barbosa

International Association of Orofacial Harmonisation – ASSIHOF, Sao Paulo, Brazil.

Josne Carla Paterno

University of Paraiba Valley, Sao Paulo, Brazil.

*Author to whom correspondence should be addressed.


Introduction: Cutaneous ageing, an inherent process with advancing time, often detrimentally impacts self-esteem due to manifestations like wrinkles, blemishes, dehydration, sagging, and reduced tissue vitality. A contemporary trend seeks natural approaches to facial rejuvenation. Injectable Platelet-Rich Fibrin (i-PRF) emerges as a noteworthy solution owing to its biological origin and autologous nature.

Materials and Methods: Evaluating i-PRF's efficacy in counteracting ageing signs, we employed a 16 MHz high-frequency ultrasound device and meticulous photographic documentation. 26 females, aged 35-55, underwent three i-PRF sessions. Statistical scrutiny utilised a paired t-test (α = 0.05) to assess dermal modifications. Self-Perception Index scores underwent Wilcoxon testing (α = 0.05) for significant enhancements. Comparisons of newly captured frontal and profile photographs (D and E) with initial images aided visible change assessment.

Results and Discussion: Compelling data analysis evidenced a notable dermal thickness increase post-intradermal i-PRF application. P-values for examined regions were: glabella (P < .00269), frontal D (P < .00018), frontal E (P < .00014), cheek D (P < .00709), and cheek E (P < .0008). These results underscore substantial dermal thickness alterations. Statistical examination of the Self-Perception Index yielded a P-value < .0001, signifying significant self-perception change post-treatment. Conclusion: Intradermal i-PRF application markedly increased dermal thickness, endorsing its potential for dermal restructuring. Furthermore, this approach presents an accessible, cost-effective, and unbiased alternative for facial rejuvenation.

Keywords: Platelet-rich Fibrin, tissue regeneration, autologous tissue, ageing, rejuvenation, facial aesthetics, ultrasound

How to Cite

Brodt, F. P., Garcia , R. P., Costa , M. F., Marchi, C. M. D., Barja , P. R., Doria , A. C. O. C., Furtado , G. R. D., Barbosa , K. L., & Paterno , J. C. (2023). Evaluation of Injectable Platelet-rich Fibrin (i-PRF) as an Autologous Tissue Regenerator in Facial Aesthetics. Journal of Advances in Medicine and Medical Research, 35(21), 97–109. https://doi.org/10.9734/jammr/2023/v35i215215


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