Does the Relationship between Endometriosis and Periodontal Disease Really Exist? A Systematic Review
Caio Vinicius G. Roman-Torres *
Post-graduate Program in Dentistry, Department of Dentistry, University Santo Amaro (UNISA), São Paulo, SP, Brazil.
Maria Eduarda Queiroz Lourenço
Post-graduate Program in Dentistry, Department of Dentistry, University Santo Amaro (UNISA), São Paulo, SP, Brazil.
Tauany Simões Ferraz
ABO - Santos/SP, Brazil.
Tatiana de Almeida Bezzi Elias
Post-graduate Program in Dentistry, Department of Dentistry, University Santo Amaro (UNISA), São Paulo, SP, Brazil.
Marcello Torres M. de Araújo
Post-graduate Program in Dentistry, Department of Dentistry, University Santo Amaro (UNISA), São Paulo, SP, Brazil.
Angela Cristina de Jesus Pereira
Post-graduate Program in Dentistry, Department of Dentistry, University Santo Amaro (UNISA), São Paulo, SP, Brazil.
Reinaldo Guedes Junior
Post-graduate Program in Dentistry, Department of Dentistry, University Santo Amaro (UNISA), São Paulo, SP, Brazil.
Fernanda Pasquinelli
Post-graduate Program in Dentistry, Department of Dentistry, University Santo Amaro (UNISA), São Paulo, SP, Brazil.
*Author to whom correspondence should be addressed.
Abstract
Background: Endometriosis and periodontitis are chronic and inflammatory diseases. Studies, assumptions and opinions try to shed light on this possible relationship. The aim of this systematic review was to investigate the association between endometriosis and periodontal disease.
Methods: The following databases: Medline, Scopus, Embase, Web of Science, Cochrane Library, and Goolge Scholar, the descriptors used were: Endometriosis and Periodontal Disease in English, during the period from 1995 to 2023. 10 abstracts were found that had submitted the entire article for inclusion analysis. The eligibility criteria were: clinical trials, observational studies, and specific studies of endometriosis with periodontal diagnosis. Case reports, laboratory studies, and studies without periodontal disease in participants were excluded. Abstracts were evaluated by two investigators.
Results: After accepting the eligibility criteria, two studies were included in this review, a cross-sectional study and a case-control study. The included studies do not allow for comparison, have different periodontal diagnostic criteria, and focus more on the biological plausibility of the increase in circulating cytokines in the body than on the observed outcomes.
Conclusion: Nowadays there is no association between endometriosis and periodontal diseases, the studies only indicate a biological plausibility, clinical studies with adequate methodological design are necessary to prove such an association.
Keywords: Endometriosis, periodontal disease, periodontitis, women's health