Journal of Advances in Medicine and Medical Research

Malignant melanoma is an aggressive neoplasm, its metastasis to bone marrow is rare phenomenon. Here, we are presenting a case of metastatic malignant melanoma to bone marrow with unknown primary in 40 years old patient along with review of literature. This case is diagnosed as metastatic malignant melanoma in bone marrow aspirate and biopsy specimen first. Diagnosis was done on the basis of classical histological features and with the help of immunohistochemistry. Radiological investigations were done to know primary site. Multiple metastasis in liver and vertebra were also identified. USG guided fine needle aspiration cytology of liver and biopsy of vertebral lesion were also performed, which confirms the diagnosis of malignant melanoma metastasis. In our case, patient died within one month after diagnosis. Early diagnosis of metastatic malignant melanoma will help clinicians to better understanding of course of disease, so they can provide best possible patient care and management. Clinicians must be aware of progression of disease, clinical manifestations of metastatic malignant melanoma.