Association of the Lipoprotein Lipase S447X and Neuropeptide Y Leu7Pro Genetic Polymorphisms with the Lipid Profiles of Individuals with and without Evidence of Coronary Artery Disease
W. O. Pinheiro
Department of Genetics and Molecular Biology, Santa Cruz State University (Universidade Estadual de Santa Cruz), Ilhéus, Bahia, Brazil.
C. R. Marques
Department of Genetics and Molecular Biology, Santa Cruz State University (Universidade Estadual de Santa Cruz), Ilhéus, Bahia, Brazil.
F. Rios-Santos
Department of Health, Federal University of Mato Grosso (Universidade Federal do Mato Grosso), Cuiabá, Mato Grosso (MT), Brazil.
M. D. B. Fernandes
Health Sciences Center, Federal University of Recôncavo da Bahia (Universidade Federal do Recôncavo da Bahia), Santo Antônio de Jesus, Bahia, Brazil.
D. B. Santos
Health Sciences Center, Federal University of Recôncavo da Bahia (Universidade Federal do Recôncavo da Bahia), Santo Antônio de Jesus, Bahia, Brazil.
S. O. T. Klein
Health Sciences Center, Federal University of Recôncavo da Bahia (Universidade Federal do Recôncavo da Bahia), Santo Antônio de Jesus, Bahia, Brazil.
F. S. Oliveira
Health Sciences Center, Federal University of Recôncavo da Bahia (Universidade Federal do Recôncavo da Bahia), Santo Antônio de Jesus, Bahia, Brazil.
A. Gonzales
Institute of Cardiology of Recôncavo da Bahia (Instituto de Cardiologia do Recôncavo da Bahia, INCAR), Santo Antônio de Jesus, Bahia, Brazil.
D. C. Freitas
Institute of Cardiology of Recôncavo da Bahia (Instituto de Cardiologia do Recôncavo da Bahia, INCAR), Santo Antônio de Jesus, Bahia, Brazil.
J. Y. Park
Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida, USA.
G. Di Pietro *
Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida, USA. and Department of Pharmacy, Federal University of Sergipe (Universidade Federal de Sergipe), Sao Cristovao, Sergipe, Brazil.
*Author to whom correspondence should be addressed.
Abstract
Background: Coronary artery disease (CAD) is a multifactorial disease whose etiogenesis involves a number of environmental, genetic and lifestyle-related factors. Genetic polymorphisms are noteworthy among these factors because they alter gene expression and, thus, the functions of the respective products.
Methods: A case-control study was conducted in the Cardiology Institute, with 79 subjects classified as cases with CAD, and 96 subjects as controls without CAD or other disease. In this study, we evaluated the association between the single-nucleotide polymorphisms (SNPs) of S447X and Leu7Pro of the lipoprotein lipase (LPL) and neuropeptide Y (NPY) genes, respectively.
Results: No differences were found in the frequencies of LPL SNP between the cases and controls. However, the LPL 447X allele carriers exhibited a near-significant difference in the triglycerides (p=0.086) and higher mean in the HDL-c (p=0.018). NPY polymorphisms proved to be infrequent in this study population, and no significant difference was observed between the groups.
Conclusions: Our findings provide further support of the genetic polymorphisms effect on the lipid metabolism control. So, further studies are needed to assess the functional effect of this and other polymorphisms, on LPL and in the NPY activity, and their impact on CAD risk.
Keywords: Coronary artery disease, lipoprotein lipase, neuropeptide Y, single-nucleotide polymorphisms