Diagnosis of Sero-negative Rheumatoid Arthritis Depending on Pathology Associated with Clinical Picture
Aliaa Mamdouh Farag
Department of Rheumatology, Physical Medicine and Rehabilitation, Faculty of Medicine, Tanta University, Tanta 31527, Egypt.
Noha Elanwar
Department of Pathology, Faculty of Medicine, Tanta University, Tanta 31527, Egypt.
Mervat Elsergany
Department of Rheumatology, Physical Medicine and Rehabilitation, Faculty of Medicine, Tanta University, Tanta 31527, Egypt.
Ali Eldeeb
Department of Rheumatology, Physical Medicine and Rehabilitation, Faculty of Medicine, Tanta University, Tanta 31527, Egypt.
Elham Kassem
Department of Rheumatology, Physical Medicine and Rehabilitation, Faculty of Medicine, Tanta University, Tanta 31527, Egypt.
*Author to whom correspondence should be addressed.
Abstract
Objectives: This study was done to assess the role of synovial tissue analysis in rheumatoid arthritis (RA) patients.
Methods: All data were recorded at baseline. All patients underwent clinical, radiologic, serologic, and histological assessments before treatment. Patients were divided into anti-citrullinated protein antibody (anti-CCP) positive and anti-CCP-negative and were compared according to different disease aspects. Correlations between clinical, laboratory, imaging, histological, and pathophysiological data were done for all patients.
Results: There were no statistically significant differences in synovial cell infiltrates according to the serology.
Conclusion: Both study groups had similar synovial cell infiltrates.
Keywords: Arthritis, rheumatoid, synovial tissue, synovitis