Changes in Plasma Adiponectin, IL-6, TNF-α and Free Fatty Acid Concentrations in Obese Japanese Men
Maki Sato *
Department of Physiology, Aichi Medical University, Nagakute, Aichi, Japan.
Dominika Kanikowska
Department of Physiology, Aichi Medical University, Nagakute, Aichi, Japan.
Satoshi Iwase
Department of Physiology, Aichi Medical University, Nagakute, Aichi, Japan.
Yuuki Shimizu
Department of Physiology, Aichi Medical University, Nagakute, Aichi, Japan.
Naoki Nishimura
Department of Physiology, Aichi Medical University, Nagakute, Aichi, Japan.
Yoko Inukai
Department of Physiology, Aichi Medical University, Nagakute, Aichi, Japan.
Junichi Sugenoya
Department of Physiology, Aichi Medical University, Nagakute, Aichi, Japan.
Motohiko Sato
Department of Physiology, Aichi Medical University, Nagakute, Aichi, Japan.
*Author to whom correspondence should be addressed.
Abstract
The risk of developing metabolic syndrome, hypertension, type 2 diabetes, and hyperlipidemia increases with obesity, and an elevated visceral fat content has been associated with a higher incidence of metabolic risk factors. We investigated differences in IL-6 (Interleukin-6), TNF-α (tumor necrosis factor-α), adiponectin and FFA (free fatty acid) levels in obese and non-obese Japanese men. Five obese men (BMI: 32.4±4.9 kg/m2) and five non-obese men (BMI: 23.2±2.9 kg/m2) participated in this study.IL-6 levels were significantly higher in obese than in non-obese subjects, whereas no significant differences were observed in TNF-α, adiponectin, or FFA levels. These results suggested that IL-6 levels may be affected more by obesity in Japanese men than TNF-α and adiponectin levels, which may, in turn, influence the pathophysiology of obesity in Japanese individuals.
Keywords: Obese, IL-6, TNF-α, adiponectin, Japanese