Journal of Advances in Medicine and Medical Research

The present study examines whether overweight and obese are inter related with low-grade systemic inflammation as measured by serum hs-CRP concentration. The present observational, cross-sectional study is from the department of medicine, CSS Hospital, Subharti Medical College, Meerut, to evaluate the profile of patients who came for routine health check-ups from December 2020 to January 2022. The study comprised 150 patients divided into three groups normotensives, normoglycemic adults of the age group 20-70 years based on BMI as Normal BMI (18.5-22.9 kg/m²), overweight (23-24.9 kg/m²) and obese (BMI>25 kg/m²), according to Asian standards by WHO. The mean age among the study subjects was 49.38±12.62 years. Out of 150 subjects, 83 (55.33%) were males and 67 (44.67%) were females. Normal, overweight, and obesity were found among 34%, 29.33%, and 36.67% of the subjects respectively. Normal and high hs-CRP was reported in 46% and 54% of the subjects respectively. The mean hs-CRP among the study subjects was 6.07±4.23. Mean FBS (mg/dL), WC (cm), TC (mg/dL), TGL (mg/dL), and HDL (mg/dL) among the study subjects was 102.94±13.03, 88.2±13.36, 161.84±52.56, 133.18±64.48 and 34.73±17.44 respectively. Mean hs-CRP was found to be highest in obese subjects (10.09±3.67) followed by overweight (6.74±2.48) and normal subjects (2.32±1.11). When hs-CRP was compared among normal vs overweight, normal vs obese, and overweight vs obese using a t-test, a significant difference was found. Pearson correlation analysis revealed a positive correlation between BMI, FBS (mg/dL), WC (cm), TC/HDL (mg/dL), TGL (mg/dL), and hs-CRP i.e. with an increase in these mentioned parameters, hs-CRP value also increases.

Conclusion: Obesity is a state of chronic inflammation that has a strong link to hs-CRP levels.