Occupational Exposure to Bisphenol A (BPA) and Its Relationship with Serum Testosterone, Adiponectin, Estradiol and Insulin Resistance
Tunmise Tope Oladipe *
Department of Medical Biochemistry, Faculty of Basic Medical Sciences, Kogi State University Anyingba, Nigeria and Department of Biochemistry, Faculty of Life Sciences, University of Benin, Nigeria.
Patrick Ojeifor Uadia
Department of Biochemistry, Faculty of Life Sciences, University of Benin, Nigeria.
*Author to whom correspondence should be addressed.
Abstract
Background: Studies on occupational exposures to Bisphenol A (BPA) and its health effects are insufficient, because most studies on the health hazards of BPA have been on the general public.
Methods: This study aimed to determine the relationship between workplace exposure to BPA, sex hormones and some metabolic parameters. Fasting blood samples were obtained from 46 occupationally exposed and 23 non-occupationally exposed adults. The levels of serum BPA, estrogen, testosterone, adiponectin, cortisol and insulin were analysed using enzyme linked immunosorbent assay (ELISA), plasma glucose, total protein and insulin resistance (HOMA-IR) were also determined.
Results: The results revealed that only 78% (n=36) of the occupationally exposed and 65% (n=15) of the non-occupationally exposed individuals had detectable serum BPA level. The results also showed that the occupationally exposed individuals had a statistically non-significant (P=0.2), greater serum BPA level (3.30±1.46ng/ml) than the non-occupationally exposed subjects (0.05±0.01ng/ml). However compared with the non–occupationally exposed group, the subjects who are occupationally exposed to BPA had a significantly higher level of serum testosterone (P=0.0003) and adiponectin (P=0.03). There were no significant differences in the serum level of estradiol (P=0.07), cortisol (P=0.28), insulin (P=0.85), plasma glucose (P=0.26), total protein (P=0.97) and insulin resistance (HOMA-IR) (P=0.46) between the two groups.
Conclusion: In conclusion this study revealed that occupational exposure to BPA results in higher serum BPA level, testosterone and adiponectin in Humans.
Keywords: Occupational exposure, bisphenol A, serum BPA, serum testosterone, adiponectin, metabolic parameters
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