Crohn’s Disease Mimicking Intestinal Tuberculosis: A Case Series
Guddi Rani Singh
Department of Pathology, Indira Gandhi Institute of Medical Sciences, Patna, India.
Bharti Kumari
Department of Pathology, Indira Gandhi Institute of Medical Sciences, Patna, India.
Mamta Kumari *
Department of Pathology, Indira Gandhi Institute of Medical Sciences, Patna, India.
Deepak Kumar
Department of Radiology, Indira Gandhi Institute of Medical Sciences, Patna, India.
Manish Mandal
Department of Gastrointestinal Surgery, Indira Gandhi Institute of Medical Sciences, Patna, India.
Bipin Kumar
Department of Pathology, Indira Gandhi Institute of Medical Sciences, Patna, India.
*Author to whom correspondence should be addressed.
Abstract
The overall estimated burden of Inflammatory bowel disease in India in 2010 came out to be 1.4 million. Aim of our study was to focus on histomorphological findings of rare Crohn’s disease and discuss the role of serum Antisaccharomyces cerevisiae (ASCA) antibody level and short standard anti-tubercular therapy for 15 days. We reported 4 cases on histopathology at our institute between june 2021 to march 2022. Both intestinal tuberculosis and Crohn’s disease are chronic granulomatous lesion , but the absence of well defined microgranuloma and caseous necrosis on histopathology are clinching point against Intestinal tuberculosis, favouring Crohn’s disease. Microbiological findings and serum ASCA antibody level were of no use in differentiating Crohn’s from tuberculosis. Early diagnosis of both entities are important as management differs from one another.
Keywords: Intestinal tuberculosis, Crohn’s disease, Antisaccharomyces cerevisiae antibody level