Study of the Role of Protein S in Patients with Coronavirus Disease 2019
Sarah Mohsen Kamel Sheta
Clinical Pathology Department, Faculty of Medicine, Tanta University, Egypt.
Jehan Abd El-Hameed El-Sharnouby
Clinical Pathology Department, Faculty of Medicine, Tanta University, Egypt.
Mohamed Sayed Hantera
Chest Diseases Department, Faculty of Medicine, Tanta University, Egypt.
Niveen Naeem Mohamed Bayoumi
Clinical Pathology Department, Faculty of Medicine, Tanta University, Egypt.
*Author to whom correspondence should be addressed.
Abstract
Background: A novel coronavirus disease 2019 (COVID 19) was found for the first time in late 2019 in Wuhan, China, and swiftly transmitted throughout the globe, resulting in a pandemic. The virus was determined as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the World Health Organization (WHO) recognized the condition as coronavirus disease 2019 (COVID-19).
Aim of the Work: To assess the role of protein S in COVID 19 cases.
Patients and Methods: Study area setting: The research was applied in Clinical Pathology Department, Faculty of Medicine, Tanta University. Group I: 15 normal subjects with matched age and sex to patient group as a control group and II: 40 patients diagnosed with PCR as COVID -19 positive. Which include 25% of patients had severe disease, 55% had moderate severity, and 20% had mild disease.
Results: COVID-19 infection has a significant influence on the blood coagulation cascade, which might result in the presentation of serious signs and elevated mortalities.
Keywords: Severe acute respiratory syndrome coronavirus 2, coronavirus disease 2019, activated protein C