Effect of Passive Transfer of Spleen Cells from Immunized Mice with Hydatid Cyst Antigens on the Growth of Melanoma Cancer in C57/Black Mice
Seyedeh Tala Ramazninia
Department of Medical Parasitology and Mycology, Isfahan University of Medical Sciences, Isfahan, Iran.
Seyedeh Maryam Sharafi
Infectious Disease and Tropical Medicine Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Mehran Bahadoran
Department of Medical Parasitology and Mycology, Isfahan University of Medical Sciences, Isfahan, Iran.
Fereshteh Jafaee Nodeh
Department of Medical Parasitology and Mycology, Isfahan University of Medical Sciences, Isfahan, Iran.
Mehdi Mahmoudzadeh
Department of Internal Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Hossein Yousofi Darani *
Department of Medical Parasitology and Mycology, Isfahan University of Medical Sciences, Isfahan, Iran.
*Author to whom correspondence should be addressed.
Abstract
Background: Anticancer effect of hydatid has been shown in previous investigations. However the mechanism of anticancer effects of hydatid cyst has not been clarified. So in this work the effect of spleen cell transfer immunized by the hydatid cyst antigens on melanoma cancer growth in animal model has been investigated.
Methods: Spleen cells of mice immunized with hydatid cyst fluid, cyst wall and protoscoleces were transferred to different group of mice and subsequently challenged with melanoma cells. Then the tumor size, tumor growth rate and survival time of mice were compared with those of control groups.
Results: Tumor size, tumor growth rate and mice survival time were significantly lower than what observed in control mice.
Conclusion: Immune response to hydatid cyst antigens may be involved in Anti-cancer effect of this parasite.
Keywords: Hydatid cyst, spleen cell transfer, melanoma.