To Evaluate Preliminary Pharmacological Screening of Plant Extract of Ficus auriculata Lour for Anti - ulcer Activity
Deepak Chandra Joshi *
Department of Pharmaceutical Sciences, Sir J. C. Bose Technical Campus, Kumaun University, Bhimtal, Uttarakhand, India and Invertis University, Bareilly, Uttar-Pradesh, India.
Nirmal Joshi
Department of Pharmaceutical Sciences, Sir J. C. Bose Technical Campus, Kumaun University, Bhimtal, Uttarakhand, India.
. Harshita
Department of Pharmaceutical Sciences, Sir J. C. Bose Technical Campus, Kumaun University, Bhimtal, Uttarakhand, India.
Tirath Kumar
Department of Pharmaceutical Sciences, Sir J. C. Bose Technical Campus, Kumaun University, Bhimtal, Uttarakhand, India.
*Author to whom correspondence should be addressed.
Abstract
Objectives: To Evaluate Preliminary Pharmacological screening of plant extract of Ficus Auriculata Lour for Anti - Ulcer activity.
Materials and Methods: The fresh leaves of plant ficus auriculata lour werecollected from the wild forest area of village Mushyoli Distt. Bageshwar (Uttarakhand), India. The identification and authentication of the plant leaf’s of ficusauriculta lour (BSI/NRC/Tech./Herb.(Ident.)/2019-20/433) was done byDr S.K.Singh Research officer Botany (Scientist E) at Botanical Survey of India, (Northern regional centre, Dehradun).
Results: The results of the pyloric ligation model showed that one or more processes were responsible for the reduction in baseline gastric output, the inhibition of ulcers index, the rise in stomach capacity, and the elevation in pH of gastric fluid. The consumption of alcoholic beverages has been shown to significantly increase the levels of reduced glutathione (GSH), while the consumption of the leaves of the Ficus auriculata tree has been shown to significantly reduce the damage to the gastric mucosa caused by the consumption of alcoholic beverages.
Conclusion: There was a greater reduction in the severity of ulcers in patients who took the ethanolic extract of Ficus auriculata. Treatment with an ethanolic extract of Ficus lour leaves at dosages of 200 and 400mg/kg body weight exhibited statistically significant anti-ulcer action (p 0.0001) on the percent protection against the formation of ulcers in models produced by indomethacin. It displays a lowered stomach ulcer index, decreased total gastric acidity, increased total gastric volume, and increased total gastric protein, in contrast to the disease control. Additionally, it demonstrates an enhanced gastric pH. All of these data point to the possibility that the high flavonoid content is responsible for some of its anti-ulcer actions.
Keywords: Ficus auriculata, anti ulcer activity, phytochemical screening, indomethacin; ethanol