Impact of Sildenafil on Smooth Muscle and Blood Vessels by Using Light and Electron Microscopy
Ehab Abou-eladab *
Faculty of Specific Education, Damietta University, New Damietta City, Egypt and Basic Science Department, Alfarabi College for Dentistry and Nursing, Jeddah, Saudi Arabia.
Heba Abdal-razzak Abdel-fattah Mahmoud
Basic Science Department, Alfarabi College for Dentistry and Nursing, Jeddah, Saudi Arabia and Histology Department, Faculty of Medicine, October 6 University, Cairo, Egypt.
Hanaa abdel Kader Ibraheem
Histology Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
Ashraf Mahmoud Kamel
Histology Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
Sameh Fawzy Elsonbaty
Histology Department, Faculty of Medicine, October 6 University, Cairo, Egypt.
Faten Shehata
Basic Science Department, Alfarabi College for Dentistry and Nursing, Jeddah, Saudi Arabia.
*Author to whom correspondence should be addressed.
Abstract
The present study aimed to examine the histological changes in the smooth muscles of corpus cavernosum and veins of rats as an eventual outcome of the ceaseless use of Sildenafil citrate. The comparison of the histological aftereffects of the veins among the control and experimental groups revealed extended thickness of tunica intima and media, as exhibited by a picture analyzer. The findings indicated that the steady usage of Sildenafil reduced smooth muscles and enabled the growth of collagen fibers in corpus cavernosum of penis and mass of veins.
Keywords: Sildenafil citrate, continuous use, corpus cavernosum, blood vessels.