Biological Mode of Action of Phospholipase A and the Signalling and Pro and Anti Inflammatory Cytokines: A Review
Roshan Kumar
Department of Pharmacology, Dev Bhoomi Institute of Pharmacy and Research, Dehradun, India.
Purabi Saha
Department of Pharmacy, Uttaranchal Institute of Pharmaceutical Science, Dehradun, India.
Ivan Kahwa
Pharm Bio-trac, ACE II, Mbarara University of Science and Technology, Uganda.
Edward Amoah Boateng
Department of Surgery, Komfo Anokye Teaching Hospital, Kumasi, Ghana.
Paul Owusu Boateng
Department of Medicine, Pentecost Hospital, Accra, Ghana.
Richard Owusu Nyarko *
School of Medicine, American International University of West Africa, The Gambia.
*Author to whom correspondence should be addressed.
Abstract
It is degraded to free triglycerides and fatty acids by the secreted phosphatases of the plant family (sPLA2s). Plants have very few sPLA2s. Plant sPLA2s' molecular, biochemical, and catalytic properties are being studied. Three-dimensional structures are also included when comparing the two groups. Glycine max is used as a benchmark for comparing various organisms, including any herbal plants and small animals. In addition, they can be used as a type of signalling molecular. The functions of SPLa2 enzymes are well understood, however their ligand activities remain a mystery. Since the last review, sPLA2-binding proteins have evolved dramatically. Promiscuous SPLa2 proteins exist in nature for evolutionary reasons that we describe. As sPLA2s have a wide range of roles in the human body, they appear to be suitable therapeutic targets. New diagnostic and therapeutic techniques can be developed by using sPLA2s to interact with other proteins.
Keywords: Mutations, SPLA2, phospholipase, clinical implications, ligands