Efficacy and Safety of Triamcinolone Injection in Keloid
Saly El-Said Ayad
Department of Dermatology and Venereology, Faculty of Medicine, Tanta University, Tanta, Egypt.
Engi Saif Shaker
Department of Dermatology and Venereology, Faculty of Medicine, Tanta University, Tanta, Egypt.
Naglaa Ibrahim Sarhan
Department of Histology, Faculty of Medicine, Tanta University, Tanta, Egypt.
Fatma Abd El-Ghaffar Abd rabo
Department of Dermatology and Venereology, Faculty of Medicine, Tanta University, Tanta, Egypt.
*Author to whom correspondence should be addressed.
Abstract
Background: A keloid scar is characterised by the production of type III (early) or type I (late) collagen. The goal of this study was to see how effective intralesional triamcinolone acetonide was in treating Keloids from a clinical and microscopic standpoint.
Methods: This prospective study included 40 patients diagnosed clinically and histologically with Keloid. Patients were given intralesional injection of triamcinolone (40mg / ml) and each 1 cm2 of keloid was injected by 0.3 ml of the solution for one session monthly for five subsequent sessions. Patients were subjected to full history taking, clinical examination [general and dermatological], digital photography of the lesions and tissue punch biopsies.
Results: Before treatment: Normal pigmentation occurred in 36(90.0%) and hyper pigmentation occurred in 4(10.0%). After treatment: Normal pigmentation occurred in 32(80.0%), hyper and hypo pigmentation occurred in 4(10.0%). Colour, itching, pliability and surface area were insignificantly different before and after treatment.
Conclusions: The triamcinolone injection was to be promising and long lasting for the suppression of symptoms related to keloids and hypertrophic scars.
Keywords: Efficacy, safety, triamcinolone, keloid