Protective Effect of Resveratrol against the Alveolar Bone Loss in Rats with Experimental Periodontitis and Acts Positively on the IL-17
JordanaHeidemann Pandini
State University of Western Parana (UNIOESTE), Cascavel, Parana, Brazil.
Lais Fernanda Pasqualotto
Periodontics and Graduate Programs in Bioscience, Health and Dentistry, State University of Western Parana (UNIOESTE), Cascavel, Parana, Brazil.
Pedro Henrique de Carli Rodrigues
State University of Western Parana (UNIOESTE), Cascavel, Parana, Brazil.
João Paulo Gonçalves de Paivaa
State University of Western Parana (UNIOESTE), Cascavel, Parana, Brazil.
Patricia Oehlmeyer Nassar
Periodontics and Graduate Programs in Bioscience, Health and Dentistry, State University of Western Parana (UNIOESTE), Cascavel, Parana, Brazil.
Carlos Augusto Nassar *
Periodontics and Graduate Programs in Bioscience, Health and Dentistry, State University of Western Parana (UNIOESTE), Cascavel, Parana, Brazil.
*Author to whom correspondence should be addressed.
Abstract
The resveratrol is a polyphenol known for its health benefits, which includes the ability to interfere in the osteoblastogenesis, which may foster adverse immunomodulators effects in the host response to periodontal disease. In the present study we evaluated the appearance of periodontal tissues of rats with experimentally induced periodontitis, by using resveratrol. Twenty-four male Wistar rats were used, in which half of the animals received a ligature around the first lower molars, then forming the groups with experimental periodontitis. Next, four groups were created: 1) Control Group (CON); 2) The Ligature Group (LIG); 3) Group Resveratrol (RSV); 4) Ligature-Resveratrol Group (LIG-RSV). The animals of the Resveratrol groups were daily dosed with 10 mg/kg of body weight of polyphenol orally, during four weeks. After 105 days of experimental period, euthanasia was performed. The results showed a significantly lower alveolar bone loss (p<0.05) in animals that received resveratrol, and still, the polyphenol was able to reduce concentration of interleukin 17 (IL-17) in the groups dosed with it. Our conclusion is that dosing rats with experimental periodontitis with resveratrol could cause a protective effect on the alveolar bone loss, in addition to act positively on the IL-17.
Keywords: Periodontitis, polyphenol, alveolar bone, resveratrol