Determining the Dynamic Contrast - Enhanced Magnetic Resonance Imaging (DCE- MRI) in Diagnosis of Pulmonary Nodules
Mona Adel El-Nenaey *
Departments of Radiology and Chest diseases, Tanta University, Tanta, Egypt.
Mohamed Mahmoud Alashwah
Departments of Radiology and Chest diseases, Tanta University, Tanta, Egypt.
Basem Ibrahim Al-Shafey
Departments of Radiology and Chest diseases, Tanta University, Tanta, Egypt.
Amr Mohamed El-Badry
Departments of Radiology and Chest diseases, Tanta University, Tanta, Egypt.
*Author to whom correspondence should be addressed.
Abstract
Objective: The aim of this study is to evaluate the role of dynamic contrast _ enhanced magnetic resonance imaging (DCE-MRI) in diagnosis of pulmonary nodules.
Patients and methods: The study was a cross-sectional study that was conducted on 30 patients with lung nodules referred to Radio diagnosis and imaging department from chest and oncology departments. By performing repeated CT within 30 days, we identified malignant nodules. The CT was repeated at 3 and 6 months which showed that the malignant pulmonary nodules increased in size and number.
Results: The maximum enhancement curve was a significant discriminator. At cut-off value of ≥ 375, the maximum enhancement curve yielded a sensitivity of 92.6% and specificity of 96% (figure 3). In contrary, the ADC value had poor diagnostic accuracy in differentiating between malignant and benign cases.
Conclusion: Dynamic contrast-enhanced MRI is valuable for diagnosis of pulmonary nodules and discrimination of benign from malignant ones.
Keywords: Computed tomography, magnetic resonance imaging, positron emission tomography, national lung screening trial with sensitivity of 92.6% and specificity of 96%