Evaluation of Intralesional Injection of 5-fluorouracil in Treatment of Vitiligo
D. M. Abo Anber
*
Dermatology and Venereology Department, Faculty of Medicine, Tanta University, Egypt.
D. A. Mohammed Ali
Pathology Department, Faculty of Medicine, Tanta University, Egypt.
R. A. El-Tatawy
Dermatology and Venereology Department, Faculty of Medicine, Tanta University, Egypt.
L. H. Elgarhy
Dermatology and Venereology Department, Faculty of Medicine, Tanta University, Egypt.
*Author to whom correspondence should be addressed.
Abstract
Background: Vitiligo is a chronic cutaneous disease characterized by depigmented patches that leave psychological impact on the patients. New treatment modalities have been developed to improve the results vitiligo with less side effects.
Objective: To evaluate intralesional injection of 5-fluorouracil in treatment of vitiligo.
Patients and Methods: The study included 20 localized stable vitiligo patients. Each patient was treated with intralesional injection of 5-fluorouracil every 2 weeks for 3 sessions followed by narrow band sessions twice weekly for 3 months.
Results: There was statistically significant repigmentation after treatment with intralesional 5-FU (mean of 50.30 ± 34.60, P value =0.001 Wilcoxon signed ranks test between before and after). 55% of patients showed >50% repigmentation. after 3 months therapy. Side effects were minimal and transient.
Conclusion: Intralesional injection of 5-FU is safe and effective in the treatment of vitiligo.
Keywords: 5-fluorouracil, carbon dioxide laser, vitiligo