Effect of Curcumin, Exelon and their Combination on Brain in Alzheimer’s Disease-Induced Rats
Mohy Eldin Abd EL-Fattah Abdel-Atty *
Chemistry Department, Faculty of Science, Suez Canal University, Egypt.
Waleed Fathi Khalil
Pharmacology Department, Faculty of Veterinary Medicine, Suez Canal University, Egypt.
Shahinda Mahmoud Mohamed
Chemistry Department, Faculty of Science, Suez Canal University, Egypt.
*Author to whom correspondence should be addressed.
Abstract
Because of the continues rising in the number of patients who have Alzheimer’s disease (AD) throughout the twenty-first century, the looking for remedies increase by scientists. The treatment of AD remains a challenge due to an incomplete understanding of' reasons that lead to the selective neurodegeneration typical of Alzheimer’s brains. Among treatment for AD, the renewed interest in curcumin is rise for its potential medication. As kind of natural product curcumin with anti-AD properties is very important for prevention and treatment. The aim of the present study was evaluated the activity of curcumin in the recession of AD induced in adult male albino rats. The results showed that treatment of AD groups with curcumin or rivastigmine experienced significant decreased in brain AChE, Aβ (1-42), and MAD levels with respect to untreated group associated with significant increase in brain GSH, SOD, and CAT. activity. Further showed combination of curcumin with rivastigmine was more efficacious in treatment of AD as compared to their effect alone.
Keywords: Alzheimer’s disease, oxidative stress, curcumin, aluminum chloride.