Role of Kisspeptin in Puberty in Humans
Ravi Kant
Division of Diabetes and Metabolism, AIIMS Rishikesh, India.
Mahendra Kumar Meena *
Division of Diabetes and Metabolism, AIIMS Rishikesh, India.
*Author to whom correspondence should be addressed.
Abstract
Kisspeptin or GPR-54 is a product of KISS 1 gene regulating the production of gonadotropin releasing hormone (GnRH), luteinizing (LH) as well follicle stimulating hormone (FSH). Both LH and FSH are important hormones for reproduction in animals as well in humans. The recognition of Kisspeptin has a landmark bearing in reproductive biology. Few recent pilot studies have convincingly proven it to be a promising molecule in treating infertile couples especially those having hypogonadotropic hypogonadism not responding to conventional treatment.
Keywords: Kisspeptin, GPR-54, gonadotropin releasing hormone, luteinizing hormone, follicle stimulating hormone, hypogonadotropic hypogonadism.