Effect of Antiasthma Medication on Blood Eosinophil Count and Serum Immunoglobulin E Levels: A Randomized Controlled Study
Wasim A. Wani
Department of Pediatrics and Neonatology, Sher-I-Kashmir Institute of Medical Sciences Hospital, Srinagar, Jammu and Kashmir, India.
Sheeraz A. Dar *
Department of Pediatrics and Neonatology, Sher-I-Kashmir Institute of Medical Sciences Hospital, Srinagar, Jammu and Kashmir, India.
Khalid M. Kawosa
Department of Pediatrics and Neonatology, Sher-I-Kashmir Institute of Medical Sciences Hospital, Srinagar, Jammu and Kashmir, India.
Mudasir Nazir
Department of Pediatrics and Neonatology, Sher-I-Kashmir Institute of Medical Sciences Hospital, Srinagar, Jammu and Kashmir, India.
Ikhlas Ahmad
Department of Pediatrics and Neonatology, Sher-I-Kashmir Institute of Medical Sciences Hospital, Srinagar, Jammu and Kashmir, India.
Asif Ahmed
Department of Pediatrics, SKIMS MC Bemina, Srinagar, Jammu and Kashmir, India.
*Author to whom correspondence should be addressed.
Abstract
Background: Asthma is a chronic inflammatory condition of lung airways resulting in episodic airflow obstruction.
Aims: The main objective of this study is to find the effect of antiasthma medication on serum IgE levels and blood eosinophil count.
Study Design: This randomized controlled trial study was performed in children aged 6-15 years of age, with clinically stable and moderate persistent asthma.
Results: The findings of this study indicate both group (Budesonide/formoterol group and budesonide group) patients experienced a significant decrease in serum IgE levels and blood eosinophil counts over the study period. However, the difference in two groups was not statistically significant.
Conclusions: Inhaled steroids are effective in controlling systemic inflammation in asthma as evidenced by a decrease in IgE levels and eosinophil counts. However addition of LABA doesn’t have any additive effect.
Keywords: Asthma, budesonide, eosinophil, IgE levels, inhaled steroids, LABA