A Rare Case Report of Duodenal Marginal Zone B-cell Lymphoma Related to Immunoproliferative Small Intestinal Disease and Associated Lymphoma (IPSID)
Ziad Aljarad *
Department of Gastroenterology, Aleppo University Hospital, Aleppo, Syria
Mahmoud Nasser
Department of Gastroenterology, Aleppo University Hospital, Aleppo, Syria
Ahmad Ghazal
Department of Surgery, Aleppo University Hospital, Aleppo, Syria
Mamdouh Alkhaled
Department of Gastroenterology, Aleppo University Hospital, Aleppo, Syria
Batol Obeed
Department of Pathology, Aleppo University Hospital, Aleppo, Syria
M. Malek Shaghaleh
Department of Internal Medicine, Aleppo University Hospital, Aleppo, Syria
M. Wafa Hamoud Alhussein
Faculty of Medicine, University of Aleppo, Aleppo, Syria
*Author to whom correspondence should be addressed.
Abstract
Marginal zone B-cell lymphoma is a unique lymphoma of the gastrointestinal tract most commonly in developing countries with poor socioeconomic conditions, poor hygiene, malnutrition, and a high degree of intestinal infections where IPSID is common.
We experienced a rare case of extranodal MZBCL in duodenum (sub type of MALT) in a 14-year-old girl who complained of epigastric pain.
Abdominal Computed Tomography (CT) with Intravenous (IV) contrast showed mixed mass infiltrate the intestinal wall with mesenteric lymphadenopathy.
Upper gastrointestinal tract endoscopy had showed obstruction in the 2nd segment of duodenum, biopsies were taken.
Pathology report according to findings refers to immunoproliferative small intestinal disease and associated lymphoma (IPSID) and by immunostains, cells features are compatible with extranodal marginal zone B cell lymphoma which is sub type of MALT lymphoma.
Keywords: Duodenum, IPSID, marginal zone B-cell lymphoma, gastrointestinal tract lymphoma.