The Effect of Omega-3 Supplementation on Serum Inflammatory Factors in Hemodialysis Patients
Yaser Salehi
Department of Internal Medicine, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
Firouzeh Moinzadeh
Isfahan Kidney Diseases Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
Mojgan Mortazavi *
Isfahan Kidney Diseases Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
Mohsen Hoseini
Isfahan University of Medical Sciences, Isfahan, Iran
Shahaboddin Dolatkhah
Isfahan University of Medical Sciences, Isfahan, Iran
Shahram Taheri
Isfahan Kidney Diseases Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
Amirhosein Salehi
Department of Internal Medicine, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
*Author to whom correspondence should be addressed.
Abstract
Background: The level of inflammatory factors such as tumor necrosis factor-alfa (TNF-α) and C-reactive protein (CRP) is increased in ESRD patients and is associated with incremental mortality in these patients. Omega-3 is known as a regulator of inflammatory system. The aim of this study is to evaluate the effect of omega-3 supplementation on TNF-α and CRP level in ESRD patients.
Methods: In this randomized _ controlled double-blind clinical trial, 54 ESRD patients were evaluated in two hemodialysis centers of Isfahan university hospitals. TNF-α and high specific-CRP (hs-CRP) were measured. In the experimental group, Patients were treated with Omega-3 capsules (1 gram capsules- Making factory Zahravi- containing Eicosapentanoic 180 mg and Dosahexanoic 120 mg) three capsules per day (3 g/day ) and the control group received placebo capsules manufactured by the Zahravi with the same shape and size for 6 consecutive months.
Results: There were no differences in CRP and TNF-α levels in the beginning and the end of study between two groups (P > 0.05).
Conclusion: We conclude that using 3 g of omega-3 per day for 6 consecutive months caused no significant effect on serum levels of TNF-α and CRP in the heamodialysis population .Further studies with larger numbers of patients and longer duration of treatment are recommended.
Keywords: End stage renal disease, omega-3, inflammatory factors.