Investigation of Dynamic Thiol-Disulfide Homeostasis in Alopecia Areata Patients
Fadime Kilinc *
Dermatology Clinic, Ankara Ataturk Training and Research Hospital, Ankara, Turkey.
Sertac Sener
Dermatology Clinic, Ankara Ataturk Training and Research Hospital, Ankara, Turkey.
Ayse Akbas
Dermatology Clinic, Ankara Ataturk Training and Research Hospital, Ankara, Turkey.
Salim Neselioglu
Biochemistry Clinic, Medical Faculty, Ankara Yildirim Beyazit University, Ankara, Turkey.
Ozcan Erel
Biochemistry Clinic, Medical Faculty, Ankara Yildirim Beyazit University, Ankara, Turkey.
Akin Aktas
Dermatology Clinic, Medical Faculty, Ankara Yildirim Beyazit University, Ankara, Turkey.
*Author to whom correspondence should be addressed.
Abstract
Background: Thiols are antioxidant, organic compounds containing sulfhydryl group on their active sites. They have important roles on preventing oxidative stress. The thiol disulfide homeostasis has a vital importance in organism. Thiol disulfide imbalance is an early indicator of oxidative stress. Alopecia areata is an autoimmune skin disorder characterized with scar-free hair loss. Its pathogenesis is still unclear. Thiol disulfide homeostasis in these patients has not been studied at all.
Objective: To evaluate the thiol disulfide homeostasis in alopecia areata patients and healthy controls.
Methods: Fortysix alopecia areata patients and 41 healty controls were included in the study. Native thiol, disulfide, total thiol levels were performed with a new and automatic spectrophotometric method. Rations of disulfide/total thiol, disulfide/ native thiol and native thiol/ total thiol were calculated as percentages.
Results: No statistically significance were detected between the values of native thiol, disulfide and total thiol in both two groups (p>0,05).
Conclusion: The dynamic thiol/ disulfide homeostasis is balance in patients with alopecia areata according to our findings. That is, the patients aren’t affected by oxidative stress. Furthermore we are suggesting that more studies with wider series should be performed.
Keywords: Alopecia areata, oxidative stress, thiol disulfide homeostasis