Protective Role of Terminalia chebula in Streptozotocin-induced Diabetic Mice for Wound Healing Activity
Anurag Singh *
Department of Kayachikitsa, Faculty of Ayurveda, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India
Ragini Srivastav
Department of Biochemistry, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India
Ajai Kumar Pandey
Department of Biochemistry, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India
*Author to whom correspondence should be addressed.
Abstract
Background: Diabetes is a chronic disease characterized by high level of glucose in the blood. Wound healing becomes a challenging position to biomedical science when associated with diabetic peoples. It becomes delay in diabetic conditions. Terminalia chebula seeds may be a best alternative for the treatment of wound healing & antidiabetic activity.
Objective: The objective of the present study was to evaluate the protective role of seeds of Terminalia chebula in Streptozotocin-Induced Diabetic Mice for Wound Healing Activity.
Materials and Methods: The rate of wound contraction and estimation of various biochemical parameters such as superoxide dismutase, lipid peroxidation and nitric oxide levels in the granulation tissue of diabetic and non-diabetic mice were considered. The extract of Terminalia chebula with the concentration of 200 mg/kg and 400 mg/kg body weight was induced through intraperitoneal in diabetic and non-diabetic mice.
Results: The results showed that seeds of Terminalia chebula were a potent source of antioxidative phenolic compounds that counteract with reactive oxygen species responsible for delayed wound healing. The seeds of Terminalia chebula significantly increased the level of superoxide dismutase, nitric oxide and decreased lipid peroxidation in granuloma tissue of diabetic mice.
Conclusions: The methanolic extract of leaves of Terminalia chebula increases the rate of angiogenesis and improves antioxidant enzymes status that eventually leads to faster wound healing in diabetic condition. However, further studies are needed to explore the biomolecules present in the leaves of Terminalia chebula that lead to faster wound healing.
Keywords: Antidiabetic, wound healing, herbal medicine, Terminalia chebula.