Potential Neuro-therapeutic Effect of Flaxseed Oil on the Striatum of Rotenone Mice Model of Parkinson’ Diseases
Philemon Dauda Shallie *
Department of Anatomy, Olabisi Onabanjo University, Nigeria
Olugbenga Olawole Olayinka
Department of Anatomy, Olabisi Onabanjo University, Nigeria
Helen Bassey Akpan
Department of Anatomy, Olabisi Onabanjo University, Nigeria
Olutoye Jibrin Otulana
Department of Anatomy, Olabisi Onabanjo University, Nigeria
Oluwole Ojo Alese
Department of Physiology, University of KwaZulu Natal, South Africa
Bamidele Richard Babatunde
Department of Anatomy, Olabisi Onabanjo University, Nigeria
Damilola Joseph Talabi
Department of Anatomy, Olabisi Onabanjo University, Nigeria
Oluwadamilola Faith Shallie
Department of Anatomy, Olabisi Onabanjo University, Nigeria
*Author to whom correspondence should be addressed.
Abstract
Aim: This study investigated the potential neuro-therapeutic effect of Flaxseed oil on the striatum of Rotenone mice model of Parkinson’ diseases’
Study Design: Fifty-six adult male and female mice (Mus musculus) weighing between 23.9-26.3 grams were used for this study. The mice were randomly placed into four groups of fourteen mice each made up of equal number of male and female: A (Control; mice pellets), B (Rotenone 3 mg/kg, IP), C (Rotenone + Flaxseed oil 0.3 ml orally), and D (0.3 ml Flaxseed + Rotenone).
Place and Duration of the Study: Department of Anatomy, Olabisi Onabanjo University. Between May and September, 2016.
Methodology: The brain were excised, weighed and appropriate sections taken and processed histology and stained with H&E and Nissl stains and immuno-cytochemically with GFAP.
Results: The results showed significant (P<0.05) reduction in the neuronal cell count, body and relative brain to body weight, which were increased by flaxseed oil treatments. Rotenone induced neural and striatal bundle degeneration which were ameliorated by flaxseed oil treatment.
Conclusion: In conclusion, the reduction in weight and neuronal derangements associated with rotenone induced Parkinson’s disease in this study were reduced or alleviated as a consequence of the treatment with flaxseed oil, and hence flaxseed oil could be considered as a potential therapeutic candidate in the management of Parkinson's disease.
Keywords: Parkinson’s disease, flaxseed oil, striatum, rotenone