Hypothyroidism and Platelet Parameter Evaluation

Main Article Content

Fatma S. Shehata
Yasser M. Abd Elraouf
Hisham A. El Serogy
Wael F. Mohamed


Aims: To evaluate the effect of subclinical and overt hypothyroidism on mean platelet volume (MPV) and platelet distribution width (PDW).

Study Design: Cross sectional study.

Place and Duration of Study: Outpatient Clinic of Diabetes, Metabolism and Endocrinology Unit in internal medicine department and clinical pathology, Tanta University, Egypt in a period between June 2018 to June 2019.

Methodology: We tested 250 subjects; 50 healthy control and 200 hypothyroid patients (all were female; age ≥18 years old age) without any medical history, then patients were subdivided into newly diagnosed group and another group on l-thyroxin treatment. Platelet parameters (MPV, PDW) were assessed in all of them.

Results: MPV & PDW is increasing in hypothyroid patients than control group (8.93 ± 0.62), more in overt group (10.88 ± 0.57) than subclinical group (10.02 ± 0.55). No significant reduction in MPV and PDW in patients on l-thyroxin treatment which suggest that l-thyroxin treatment couldn’t produce difference till patients reaching their target level being euthyroid.

Conclusion: We recommend the usefulness of MPV and PDW as inexpensive markers of platelet activation in diagnostic work-up of athero-thrombotic complications risk in patients with subclinical and overt hypothyroidism.

Hypothyroidism, platelet activation, mean platelet volume (MPV), platelet distribution width (PDW), cardiovascular risk.

Article Details

How to Cite
Shehata, F. S., Elraouf, Y. M. A., Serogy, H. A. E., & Mohamed, W. F. (2020). Hypothyroidism and Platelet Parameter Evaluation. Journal of Advances in Medicine and Medical Research, 32(21), 25-34. https://doi.org/10.9734/jammr/2020/v32i2130692
Original Research Article


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