Hypothyroidism and Platelet Parameter Evaluation

Main Article Content

Fatma S. Shehata
Yasser M. Abd Elraouf
Hisham A. El Serogy
Wael F. Mohamed

Abstract

Aims: To evaluate the effect of subclinical and overt hypothyroidism on mean platelet volume (MPV) and platelet distribution width (PDW).

Study Design: Cross sectional study.

Place and Duration of Study: Outpatient Clinic of Diabetes, Metabolism and Endocrinology Unit in internal medicine department and clinical pathology, Tanta University, Egypt in a period between June 2018 to June 2019.

Methodology: We tested 250 subjects; 50 healthy control and 200 hypothyroid patients (all were female; age ≥18 years old age) without any medical history, then patients were subdivided into newly diagnosed group and another group on l-thyroxin treatment. Platelet parameters (MPV, PDW) were assessed in all of them.

Results: MPV & PDW is increasing in hypothyroid patients than control group (8.93 ± 0.62), more in overt group (10.88 ± 0.57) than subclinical group (10.02 ± 0.55). No significant reduction in MPV and PDW in patients on l-thyroxin treatment which suggest that l-thyroxin treatment couldn’t produce difference till patients reaching their target level being euthyroid.

Conclusion: We recommend the usefulness of MPV and PDW as inexpensive markers of platelet activation in diagnostic work-up of athero-thrombotic complications risk in patients with subclinical and overt hypothyroidism.

Keywords:
Hypothyroidism, platelet activation, mean platelet volume (MPV), platelet distribution width (PDW), cardiovascular risk.

Article Details

How to Cite
Shehata, F. S., Elraouf, Y. M. A., Serogy, H. A. E., & Mohamed, W. F. (2020). Hypothyroidism and Platelet Parameter Evaluation. Journal of Advances in Medicine and Medical Research, 32(21), 25-34. https://doi.org/10.9734/jammr/2020/v32i2130692
Section
Original Research Article

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