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Chronic recurrent aphthous stomatitis (CRAC) is a chronic disease of the oral mucosa, characterized by periodic remissions and exacerbations with the eruption of aft. According to WHO, it affects up to 20% of the population. Currently, most scientists are inclined to the leading role of the immune system in the pathogenesis of the disease. It has been established that with increasing severity of the disease T-suppression of immunity increases, which is characterized by a decrease in the number of T-lymphocytes and their functional activity. The increase in the number of T-suppressor cells accompanied by a decrease in the number of T-helper cells. The severity and duration of the disease correspond to the severity of the sensitization of the body with these antigens. The work was carried out based on scientific-educational practical dental center at the Bukhara State Medical Institute of Therapeutic Dentistry. A clinical examination of 67 patients aged 25–35 years with chronic recurrent aphthous stomatitis was conducted, 14 healthy individuals were included in the control group.
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