Serum Chemerin and Cardiovascular Risk Factors in Diabetic Subjects without Established Vascular Disease
Eman M. Alissa *
Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia and Elemental Spectroscopy Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia
Sara R. Helmi
Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia
Nabeel A. Alama
Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia
Gordon A. Ferns
Medical Education and Metabolic Medicine, Brighton and Sussex Medical School, University of Brighton, BN1 9PH, UK
*Author to whom correspondence should be addressed.
Abstract
Aims: The current study aims to investigate serum chemerin as a potential cardiovascular marker in diabetic patients without established vascular diseases.
Study Design: Case-Control study.
Place and Duration of Study: The outpatients clinic, King Abdulaziz University Hospital in Jeddah, Saudi Arabia, between January 2013 and June 2014.
Methodology: Ninety consecutive diabetic patients and 90 age- and sex-matched controls were recruited from King Abdulaziz University Hospital in Jeddah, Saudi Arabia. Demographic, anthropometric and biochemical variables were estimated.
Results: Overall and central obesity were highly prevalent among both groups. Serum chemerin was correlated with glycated hemoglobin (r= -0.207, p<0.05) and with C reactive protein (CRP) (r= 0.171, p<0.05). Moreover, serum chemerin was correlated with prothrombin time (r = -0.278, p<0.05) in control subjects and with diastolic blood pressure (r = -0.233, p<0.05) in diabetic subjects.
Conclusion: We concluded that only glycated hemoglobin was significantly and independently correlated with serum chemerin levels.
Keywords: Chemerin, diabetes mellitus, insulin resistance, inflammation, C reactive protein