Cell-based Wound Healing: Mechanisms and Treatments
Swarup K. Chakrabarti
DiponEd BioIntelligence, Bangalore, Karnataka, 560037, India
Raja Bhattacharya
Calcutta Medical College, 88 College Street, Kolkata, West Bengal, 700073, India
Kaushik D. Deb *
DiponEd BioIntelligence, Bangalore, Karnataka, 560037, India
*Author to whom correspondence should be addressed.
Abstract
The ultimate goal of the treatment of wounds is to restore the damaged skin both structurally and functionally to its original state. Conventional treatment of chronic wounds does not seem to work in several cases, so it is necessary to develop different strategies. Recent research advances have shown the great potential of cell-based therapies in improving the pace and quality of wound healing and skin regeneration. Cell-based therapy is thus considered a new alternative to classic methods of wound healing. This review seeks to give an updated overview of the applications of cell-based therapy in wound management. Even though cell therapy is a relatively new tool, several studies prove these types of cells can be used safely, and they have demonstrated their efficacy in healing wounds in several cases.
Keywords: Wounds, platelet-rich plasma, platelet-rich-fibrin matrix, biomaterials, stem cells.