A Brief Review of Mucormycosis: Report of Five Cases
Esmaeil Faraji
Department of Internal Medicine, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
Mohammad Reza Jafari Nakhjavani
Department of Rheumatology, Connective Tissue Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Omid Mashrabi
Department of Internal Medicine, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
Shiva Farajpour Maleki
Department of Ophthalmology, Retinal diseases Research Center, Nikookari Eye Hospital, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
Ramin Farajpour Maleki *
Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran and Neuroscience Research Center (NSRC), Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
*Author to whom correspondence should be addressed.
Abstract
Mucormycosis is an emerging and slowly rising fatal infectious disease in most countries. It is the third most common invasive mycosis after candidiasis and aspergillosis. Hematologic malignancies notably acute myeloblastic leukemia (AML) and diabetes mellitus (DM) especially when uncontrolled or there is ketoacidosis are the most common predisposing conditions. Clinical manifestations vary according to the organ involved. Based on anatomic localization, mucormycosis can be classified as one of 6 forms: Rhinocerebral, Pulmonary, Cutaneous, Gastrointestinal, Disseminated and Uncommon presentations.
The mortality rate is often very high. Early diagnosis and aggressive treatment are the cornerstone of management. Here we report 5 cases of mucormycosis in patients admitted to Imam Reza hospital, the tertiary referral center in Northwest of Iran. We will also have a brief review of this fungal infection.
Keywords: Mucor, mucormycosis, diabetes mellitus, sinusitis