Integrins and Reorganization of Osteoclast Cytoskeleton under Orthodontic Force
Jie Feng
Department of Orthodontics, State Key Laboratory of Oral Disease, West China School of Stomatology, Sichuan University, Chengdu, P.R. China.
Yang Xu
Department of Orthodontics, State Key Laboratory of Oral Disease, West China School of Stomatology, Sichuan University, Chengdu, P.R. China.
Li Xu
Department of Orthodontics, State Key Laboratory of Oral Disease, West China School of Stomatology, Sichuan University, Chengdu, P.R. China.
Qiuyue Guan
Department of Geriatrics, People’s Hospital of Sichuan Province, Chengdu, P.R. China.
Zheng Wang
Department of Orthodontics, State Key Laboratory of Oral Disease, West China School of Stomatology, Sichuan University, Chengdu, P.R. China.
Ding Bai
Department of Orthodontics, State Key Laboratory of Oral Disease, West China School of Stomatology, Sichuan University, Chengdu, P.R. China
Xianglong Han *
Department of Orthodontics, State Key Laboratory of Oral Disease, West China School of Stomatology, Sichuan University, Chengdu, P.R. China.
*Author to whom correspondence should be addressed.
Abstract
Integrins are mechanoreceptors and mediate mechanotransduction by transferring forces into focal adhesions. Osteoclastogenesis starts with adhesion to the bone matrix, leading to cytoskeleton reorganization that is important for osteoclast polarization and migration. However, there are several signaling pathways mediating this process, and integrins have been shown to be important signaling molecules participating osteoclastogenesis. Particularly, integrins have played an important role in both force transduction and osteoclastogenesis. This paper reviewed the findings on the relationship between integrins and reorganization of osteoclast cytoskeleton under orthodontic force.
Keywords: Orthodontic force, integrin, osteoclastogenesis, cytoskeleton