Role of Different Ovulation Induction Protocols in Follicular Growth, Estradiol and Pregnancy Rates for Women with Unexplained Infertility and Polycystic Ovary Syndrome Undergoing Intrauterine Insemination
Muhammad-Baqir M-R. Fakhrildin
Department of Medical Physiology, College of Medicine, Jabir Ibn Hayyan Medical University, AL-Najaf, Iraq
Sundus Fadhil Hantoosh *
Department of Training and Development, Research and Training Forensic DNA Centre, AL-Nahrain University, Baghdad, Iraq
Rajwa Hasen Essa
Department of Biology, College of Science, AL-Mustansiriya University, Baghdad, Iraq
Manal Taha Meteab
Department of Reproductive Physiology, High Institute of Infertility Diagnosis and Assisted Reproductive Technologies, AL-Nahrain University, Baghdad, Iraq
*Author to whom correspondence should be addressed.
Abstract
Introduction: The study aimed to study the effects of ovulation induction programs on the number of pre-ovulatory dominant follicles and endometrial thickness, their effects on pre-ovulatory estradiol 2 levels, and to determine the favored ovulation induction protocol to attain better pregnancy results in polycystic ovary syndrome and unexplained infertility women.
Materials and Methods: Twenty unexplained infertile and thirty polycystic ovary syndrome women subjected to ovulation induction/intrauterine insemination were enrolled in this study. First ovulation induction protocol involved clomiphene citrate only, the second involved Gonal-f only, and the third involved combination of clomiphene citrate and Gonal-f. Immediately before triggering of ovulation, follicular parameters, endometrial thickness, and estradiol 2 mean levels were measured.
Results: Only two (4%) subjected to combination of clomiphene citrate and Gonal-f became pregnant. Combination of clomid and Gonal-f yielded better pre-ovulatory endometrial thickness and higher pre-ovulatory estradiol 2 mean levels for all cases.
Conclusions: Combination of clomid and Gonal-f attained better results.
Keywords: Clomid, Gonal-f, differentiated follicles, endometrial thickness, estradiol 2